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  1. Sepsis-induced acute lung injury (ALI) is a clinical condition with high morbidity and mortality, and impaired endothelial function is the main pathological characteristic. As a member of DNA demethylases, ten...

    Authors: Hongxue Fu, Bin Gao, Xin Zhou, Yingting Hao, Chang Liu, Ailin Lan, Jingyi Tang and Fachun Zhou
    Citation: Cellular & Molecular Biology Letters 2025 30:60
    Content type: Research Article Published on:

  2. Platinum-based chemotherapy is commonly used to treat non-small cell lung cancer (NSCLC); however, innate and acquired resistance is clinically seen in many patients. Hence, a combinatorial approach with novel...

    Authors: Ji Hae Lee, Seung Hee Seo, Jaegal Shim, Yong-Nyun Kim and Kyungsil Yoon
    Citation: Cellular & Molecular Biology Letters 2025 30:59
    Content type: Research Article Published on:

  3. Testicular aging has profound effects on spermatogenesis, sperm function, and the spermatogenic microenvironment, contributing to reduced male fertility. However, the precise molecular mechanisms by which mito...

    Authors: Jun Yu, Qiuru Huang, Yangbo Fu, Lei He, Cong Shen, Xia Chen, Zhiran Li, Jiaxin Li, Chenyu Wang, Xinda Wang, Binbin Yang, Ziwen Lin, Chen Qiao, Xiaofang Tan, Xiaoqing Yang, Hao Chen…
    Citation: Cellular & Molecular Biology Letters 2025 30:58
    Content type: Research Article Published on:

  4. Acute pancreatitis (AP) is a sterile inflammation, and 10–20% of cases can progress to severe acute pancreatitis (SAP), which seriously threatens human life and health. Neutrophils and their extracellular trap...

    Authors: Qiang Wang, Xiao Zhang, Chenglong Han, Zhenyi Lv, Yi Zheng, Xuxu Liu, Zhiwei Du, Tianming Liu, Dongbo Xue, Tao Li and Liyi Wang
    Citation: Cellular & Molecular Biology Letters 2025 30:57
    Content type: Research Article Published on:

  5. Hepatocellular carcinoma (HCC) is the sixth most prevalent cancer globally and the third leading cause of cancer-related mortality. Protein ubiquitination and deubiquitination play vital roles in human cancers...

    Authors: Qingwei Zhu, Zibo Yuan, Qiang Huo, Qiliang Lu, Qingsong Wu, Junwei Guo, Wen Fu, Ying Lu, Lei Zhong, Wenzhong Shang, Di Cui, Shuangshuang Li, Xin Liu, Kangsheng Tu, Dongsheng Huang, Qiuran Xu…
    Citation: Cellular & Molecular Biology Letters 2025 30:56
    Content type: Research Article Published on:

  6. Ras homolog gene family-guanosine triphosphatases (Rho-GTPases), key molecular switches regulating cytoskeletal dynamics and cellular signaling, play a pivotal role in viral infections by modulating critical p...

    Authors: Beibei Zhang, Shuli Li, Juntao Ding, Jingxia Guo, Zhenghai Ma and Hong Duan
    Citation: Cellular & Molecular Biology Letters 2025 30:55
    Content type: Review Published on:

  7. Age-related macular degeneration (AMD) is an eye disease that can lead to legal blindness and vision loss. In its advanced stages, it is classified into dry and neovascular AMD. In neovascular AMD, the formati...

    Authors: Janusz Blasiak, Elzbieta Pawlowska, Hanna Helotera, Maksim Ionov, Marcin Derwich and Kai Kaarniranta
    Citation: Cellular & Molecular Biology Letters 2025 30:54
    Content type: Review Published on:

  8. Sarcopenia, characterized by a progressive loss of skeletal muscle mass and function, is associated with the accumulation of senescent muscle stem cells, which impair muscle regeneration and contributes to the...

    Authors: Sujin Kim, Bonsang Gu, Chan-Young So, Keren Esther Kristina Mantik, Seung-Hyun Jung, Sohee Moon, Dong-Ho Park, Hyo-Bum Kwak, Jinkyung Cho, Eun-Jeong Cho, Jae-Seon Lee and Ju-Hee Kang
    Citation: Cellular & Molecular Biology Letters 2025 30:53
    Content type: Research Article Published on:

  9. Arginine auxotrophy has been reported in a subset of cancers with inherently defective de novo arginine synthesis. However, the use of arginine deprivation therapy seems to be unequally effective, partially ow...

    Authors: Vu T. A. Vo, Le Nhat Tran, Thu Thanh Bui, Han-Woong Lee and Yangsik Jeong
    Citation: Cellular & Molecular Biology Letters 2025 30:52
    Content type: Brief Report Published on:

  12. Systemic lupus erythematosus (SLE), influenced by gut microbiota dysbiosis, is characterized by autoimmune and inflammatory responses. Human umbilical cord-derived mesenchymal stem cell (hUC-MSC) transplantati...

    Authors: Quanren Pan, Fengbiao Guo, Jiaxuan Chen, Haimin Huang, Yanyan Huang, Shuzhen Liao, Zengzhi Xiao, Xi Wang, Liuyong You, Lawei Yang, Xuemei Huang, Haiyan Xiao, Hua-Feng Liu and Qingjun Pan
    Citation: Cellular & Molecular Biology Letters 2025 30:49
    Content type: Research Article Published on:

  13. Prostate cancer (PCa) is the second most common cancer affecting men globally, especially those aged 50 years and above. Despite substantial progress in terms of both prognosis and therapy, PCa remains a signi...

    Authors: Daniela Claudia Maresca, Evelina La Civita, Benedetta Romano, Maria Rosaria Ambrosio, Fabio Somma, Tania Wyss, Bernardo Rocco, Valentina Rubino, Luigi Cari, Philippe Krebs, Antonio Rodriguez-Calero, Matteo Ferro, Sara Trabanelli, Camilla Jandus, Felice Crocetto, Angela Ianaro…
    Citation: Cellular & Molecular Biology Letters 2025 30:48
    Content type: Research Article Published on:

  14. Tolerogenic dendritic cells (toDCs) are critical for maintaining immune homeostasis and preventing autoimmune disease development, such as type 1 diabetes (T1D). We have previously shown that DCs of non-obese ...

    Authors: Farhan Ullah Khan, Puregmaa Khongorzul, Denis Gris and Abdelaziz Amrani
    Citation: Cellular & Molecular Biology Letters 2025 30:47
    Content type: Research Article Published on:

  16. Osteosarcoma is the most prevalent primary malignant bone tumor affecting pediatric and adolescent individuals. However, despite the passage of three decades, there has been no notable enhancement in the overa...

    Authors: Junkai Chen, Hongbo Li, Qinglin Jin, Xiaoguang Li, Yiwen Zhang, Jingnan Shen, Gang Huang, Junqiang Yin, Changye Zou, Xinyu Li, Xin He, Xianbiao Xie and Tiao Lin
    Citation: Cellular & Molecular Biology Letters 2025 30:45
    Content type: Research Article Published on:

  17. Despite exhaustive research efforts, integrated genetic and epigenetic mechanisms contributing to tobacco-induced initiation and progression of lung cancers have yet to be fully elucidated. In particular, limi...

    Authors: Sichuan Xi, Jigui Shan, Xinwei Wu, Haitao Wang, Mary R. Zhang, Shakirat Oyetunji, Hong Xu, Zuoxiang Xiao, Tuana Tolunay, Shamus R. Carr, Chuong D. Hoang and David S. Schrump
    Citation: Cellular & Molecular Biology Letters 2025 30:44
    Content type: Research Article Published on:

  19. Ischemia–reperfusion (I/R) injury describes the pathological process wherein tissue damage, initially caused by insufficient blood supply (ischemia), is exacerbated upon the restoration of blood flow (reperfus...

    Authors: Lingxuan Tang, Wangzheqi Zhang, Yan Liao, Weijie Wang, Xiaoming Deng, Changli Wang and Wenwen Shi
    Citation: Cellular & Molecular Biology Letters 2025 30:42
    Content type: Review Published on:

  20. The incidence of atherosclerosis markedly rises following menopause. Our previous findings demonstrated that elevated follicle-stimulating hormone (FSH) levels in postmenopausal women accelerate atherosclerosi...

    Authors: Ping Li, Yixiao Xiang, Jinzhi Wei, Xingyan Xu, Jiale Wang, Haowei Yu, Xiaosa Li, Huiping Lin and Xiaodong Fu
    Citation: Cellular & Molecular Biology Letters 2025 30:41
    Content type: Research Article Published on:

  21. Lung cancer is the most frequently diagnosed malignancy and the leading cause of cancer-related mortality worldwide. Similar to other solid tumors, the development of non-small cell lung cancer (NSCLC) is beli...

    Authors: Zhipeng Wang, Yan Wu, Ziqi Ding, Xinru Xiao, Yanhua Huang, Zhiguang Liu and Qian Zhang
    Citation: Cellular & Molecular Biology Letters 2025 30:40
    Content type: Research Article Published on:

  22. Although hepatic ischemia–reperfusion injury (IRI) frequently occurs during liver resection and transplantation, the underlying mechanisms remain incompletely understood. Through high-throughput sequencing, we...

    Authors: Dengliang Lei, Yihua Wang, Shanshan Li, Song Xiang, Yunhai Luo, Ping Yan, Fang Luo, Zuotian Huang and ZhongJun Wu
    Citation: Cellular & Molecular Biology Letters 2025 30:39
    Content type: Research Article Published on:

  23. Fibroblast-like synoviocytes (FLS) are crucial for maintaining synovial homeostasis. SMYD5, a member of the histone lysine methyltransferase subfamily SMYDs, is involved in many pathological processes. This st...

    Authors: Chenxi Xiao, Zhenghua Su, Jialin Zhao, Subei Tan, Mengting He, Yuhui Li, Jiayao Liu, Jie Xu, Yajie Hu, Zhongzheng Li, Chunxiang Fan and Xinhua Liu
    Citation: Cellular & Molecular Biology Letters 2025 30:38
    Content type: Research Article Published on:

  24. Tumor immune escape is a pivotal gateway for esophageal squamous cell carcinoma (ESCC) development. Immune checkpoint-blocking therapies, represented by programmed cell death receptor-1/ligand 1 (PD-1/PD-L1) i...

    Authors: Chang Wang, Chenxi Ju, Dan Du, Peiyu Zhu, Jie Yin, Jinlin Jia, Xue Wang, Xinyu Xu, Li Zhao, Junhu Wan, Ting Sun, Lijun Yang, Hongle Li, Fucheng He, Mingxia Zhou and Jing He
    Citation: Cellular & Molecular Biology Letters 2025 30:37
    Content type: Research Article Published on:

  25. Chromatin remodeler chromodomain helicase DNA-binding protein 8 (CHD8) defines a subtype of autism that is associated with immune disorders. It remains unknown whether CHD8 plays a cell-intrinsic role in immun...

    Authors: Jun-Qi Yang, Chen Wang, Ramesh C. Nayak, Manohar Kolla, Mingjun Cai, Mario Pujato, Yi Zheng, Q. Richard Lu and Fukun Guo
    Citation: Cellular & Molecular Biology Letters 2025 30:36
    Content type: Research Article Published on:

  27. Klebsiella pneumoniae (KP) infections represent a significant global health challenge, characterized by severe inflammatory sequelae and escalating antimicrobial resistance. This comprehensive review elucidates t...

    Authors: Yangguang Li, Xuanheng Li, Wenqi Wu, Peizhao Liu, Juanhan Liu, Haiyang Jiang, Liting Deng, Chujun Ni, Xiuwen Wu, Yun Zhao and Jianan Ren
    Citation: Cellular & Molecular Biology Letters 2025 30:34
    Content type: Mini Review Published on:

  29. The receptor recognition and interaction of plasma lipoproteins (e.g., native low-density lipoproteins (LDL)/oxidized low-density lipoproteins (oxLDL), as well as the influence of microenvironmental/lysosomal ...

    Authors: Kun Wang, Chenhan Sun, Hongda Zhuang, Xian-Cheng Jiang and Yong Chen
    Citation: Cellular & Molecular Biology Letters 2025 30:32
    Content type: Research Article Published on:

  30. Neuropathic pain is a complex condition resulting from damage or disease in the somatosensory nervous system, causing significant physical and emotional distress. Despite its profound impact, the underlying ca...

    Authors: Hyun Jun Jang, Juhee Shin, Sangkyu Lee, Boyoung Lee and Dong Woon Kim
    Citation: Cellular & Molecular Biology Letters 2025 30:31
    Content type: Research Article Published on:

  31. ATP-dependent switch/sucrose nonfermenting-type chromatin remodeling complexes (SWI/SNF CRCs) are multiprotein machineries altering chromatin structure, thus controlling the accessibility of genomic DNA to var...

    Authors: Anna Maassen, Jaroslaw Steciuk, Magdalena Wilga, Jakub Szurmak, Damian Garbicz, Elzbieta Sarnowska and Tomasz J. Sarnowski
    Citation: Cellular & Molecular Biology Letters 2025 30:30
    Content type: Review Published on:

  32. Doxorubicin (DOX) is a potent anticancer drug; however, it is associated with significant cardiotoxicity. CDC20 is an E3 ubiquitin ligase that plays a role in cell cycle progression and apoptosis in various ty...

    Authors: Zhenyu Feng, Ningning Zhang, Liang Wang, Xumin Guan, Yunpeng Xie and Yun-long Xia
    Citation: Cellular & Molecular Biology Letters 2025 30:29
    Content type: Research Article Published on:

  33. Recurrent spontaneous abortion (RSA) affects approximately 1–5% of childbearing women and poses a significant threat to global reproductive health. Transfer RNA-derived small RNAs (tsRNAs) are a novel class of...

    Authors: Jialyu Huang, Jiawei Wang, Shuang Wang, Xiangpeng Xiong, Ruiyin Jiang, Chaoyi Xiong, Lu Wang, Lingling Huang, Yan Zhao, Zheng Fang, Xiaoyan Ai and Jiaying Lin
    Citation: Cellular & Molecular Biology Letters 2025 30:28
    Content type: Research Article Published on:

  34. The "War on Cancer" began with the National Cancer Act of 1971 and despite more than 50 years of effort and numerous successes, there still remains much more work to be done. The major challenge remains the co...

    Authors: Paulina Czechowicz, Anna Więch-Walów, Jakub Sławski, James F. Collawn and Rafal Bartoszewski
    Citation: Cellular & Molecular Biology Letters 2025 30:27
    Content type: Mini Review Published on:

  35. The intramuscular fat (IMF) content of yak beef is critical for determining its quality. Circular RNAs (circRNAs) are a group of endogenous non-coding RNAs that have emerged as important factors in the regulat...

    Authors: Chunyu Qin, Fang Xu, Binglin Yue, Jincheng Zhong, Zhixin Chai and Hui Wang
    Citation: Cellular & Molecular Biology Letters 2025 30:26
    Content type: Research Article Published on:

  36. The DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a key kinase in the DNA repair process that responds to DNA damage caused by various factors and maintains genomic stability. However, DNA-PKcs ...

    Authors: Jiabao Hou, Mingjun Lu, Jingwei Guo, Jinghong Wu, Chenyang Wang, Ping-Kun Zhou and Teng Ma
    Citation: Cellular & Molecular Biology Letters 2025 30:25
    Content type: Mini Review Published on:

  37. Adipose-derived stem cells (ADSCs) have been shown to accelerate diabetic wound healing by promoting neovascularization, though the underlying mechanisms are not fully understood. This study aims to explore wh...

    Authors: Yunjia Xie, Xuejun Ni, Xiaofen Wan, Nating Xu, Lu Chen, Chensheng Lin, Xi Zheng, Beichen Cai, Qian Lin, Ruonan Ke, Tao Huang, Xuefeng Hu, Biao Wang and Xiuying Shan
    Citation: Cellular & Molecular Biology Letters 2025 30:24
    Content type: Research Article Published on:

  38. Drug resistance in metastatic lung cancer significantly contributes to patient mortality. This study explores the role of circulating tumor cells (CTCs), the precursors to metastasis, in driving this resistanc...

    Authors: Zujun Que, Dan Qi, Yun Yang, Wang Yao, Jiajun Liu, Yan Li, Yuanyuan Yu, Luyao Wang, Fangfei Li, Ge Zhang, Erxi Wu and Jianhui Tian
    Citation: Cellular & Molecular Biology Letters 2025 30:23
    Content type: Research Article Published on:

  39. Age-dependent accumulation of lipofuscin in the retinal pigment epithelium (RPE) is closely related to the etiology of autosomal recessive Stargardt’s disease (STGD1) and dry age-related macular degeneration (...

    Authors: Bo Yang, Kunhuan Yang, Yuling Chen, Qingjian Li, Jingmeng Chen, Shiying Li and Yalin Wu
    Citation: Cellular & Molecular Biology Letters 2025 30:22
    Content type: Research Article Published on:

  40. Cyclophosphamide (CTX) is the first-line medication for the treatment of breast cancer, although it potentially leads to severe ovarian dysfunction and even premature ovarian failure (POF). However, the mechan...

    Authors: Hao-Cheng Gu, Ling-Fang Wang, Yu-Wei Zhang, You-Qiong Zhuo, Zhou-Hang Zhang, Xing-Yu Wei, Quan-Wen Liu, Ke-Yu Deng and Hong-Bo Xin
    Citation: Cellular & Molecular Biology Letters 2025 30:21
    Content type: Research Article Published on:

  41. Recent studies have illuminated the complexities of treating advanced bladder cancer (BCa), underscoring the importance of comprehending its molecular mechanisms for creating novel therapies. While the role of...

    Authors: Cong Yin, Cen Liufu, Shuai Ye, Tao Zhu, Jiahao Jiang, Mingxia Wang, Liqun Zhou, Lin Yao, Yan Wang and Bentao Shi
    Citation: Cellular & Molecular Biology Letters 2025 30:20
    Content type: Research Article Published on:

  43. Atherosclerosis, with its complex pathogenesis, is a leading underlying cause of many cardiovascular diseases, which are increasingly prevalent in the population. Sphingolipids play an important role in the de...

    Authors: Fufangyu Zhao, Mingyan Shao, Mingrui Li, Tianxing Li, Yanfei Zheng, Wenlong Sun, Cheng Ni and Lingru Li
    Citation: Cellular & Molecular Biology Letters 2025 30:18
    Content type: Mini Review Published on:

  45. Neuropathic pain (NP) represents a debilitating and refractory condition. However, the understanding of NP and the current treatment approaches available for its management are limited. Therefore, there is a s...

    Authors: Jinshi Li, Yang Guo, Chen Zhu, Dongxu Wang, Yuan Li, Xiaotong Hao, Linyan Cao, Yiting Fan and Bo Fang
    Citation: Cellular & Molecular Biology Letters 2025 30:16
    Content type: Research Article Published on:

  46. Circular (circ)RNAs have emerged as crucial contributors to cancer progression. Nonetheless, the expression regulation, biological functions, and underlying mechanisms of circRNAs in mediating hepatocellular c...

    Authors: Xindong Wei, Anfeng Si, Shuai Zhao, Yi Fu, Jilei Li, Kedeerya Aishanjiang, Yujie Ma, Chang Yu, Bo Yu, Chunhong Cui, Hui Wang, Xianming Kong, Shibo Li, Xiaoni Kong, Ying Tong and Hailong Wu
    Citation: Cellular & Molecular Biology Letters 2025 30:15
    Content type: Research Article Published on:

  47. The protein cereblon (CRBN) mediates the antileukemia effect of lenalidomide (Len). Len binds to CRBN, recruits IKZF1/IKZF3, and promotes their ubiquitination and degradation, through which Len exhibits its an...

    Authors: Lu Zou, Dan Cao, Qing Sun, Wenjun Yu, Bingzong Li, Guoqiang Xu and Liang Zhou
    Citation: Cellular & Molecular Biology Letters 2025 30:14
    Content type: Brief Report Published on:

  48. Shiga toxin (Stx)-induced hemolytic uremic syndrome (HUS) poses a life-threatening complication for which a definitive treatment remains elusive. To exert its cytotoxic effect on renal cells, Stx must be deliv...

    Authors: Xinlei Sun, Shuang Qu, Fenglian Zhou, Fujie Shi, Yunfei Wu, Lin Gu, Minghui Liu, Zhen Bian, Lei Shi, Zhihong Liu, Yuan Liu and Ke Zen
    Citation: Cellular & Molecular Biology Letters 2025 30:13
    Content type: Research Article Published on:

  49. Vacuolization of hematopoietic precursors cells is a common future of several otherwise non-related clinical settings such as VEXAS, Chediak–Higashi syndrome and Danon disease. Although these disorders have a ...

    Authors: Coline Savy, Maxence Bourgoin, Thomas Cluzeau, Arnaud Jacquel, Guillaume Robert and Patrick Auberger
    Citation: Cellular & Molecular Biology Letters 2025 30:12
    Content type: Mini Review Published on:

  50. Breast cancer is the most commonly diagnosed type of cancer and the leading cause of cancer-related death in women worldwide. Highly targeted therapies have been developed for different subtypes of breast canc...

    Authors: Vittoria Marchio, Giuseppina Augimeri, Catia Morelli, Adele Vivacqua, Cinzia Giordano, Stefania Catalano, Diego Sisci, Ines Barone and Daniela Bonofiglio
    Citation: Cellular & Molecular Biology Letters 2025 30:11
    Content type: Review Published on:

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Cellular & Molecular Biology Letters

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