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Articles

Page 1 of 24

  1. Abnormal climate change seriously endangers the safety of outdoor work and life, often causing hypothermia-induced coma or death. As the underlying mechanism has not been fully elucidated, a targeted treatment...

    Authors: Song-Jun Wang, Chao-Long Lu, Fu Zhang, Xue-Tong Dong, Xiao-Rui Su, Jing-Jing Sha, Bin Cong and Xia Liu
    Citation: Cellular & Molecular Biology Letters 2025 30:87
    Content type: Research Article Published on:

  2. It is estimated that over 85% of human transcripts are non-coding RNAs, which play an important role in the regulation of numerous biological processes and are closely associated with the development of human ...

    Authors: Lingwei Zhang, Hong Chen, Yangmei Yang, Liangbo Zhao, Huimin Xie, Peixian Li, Xinrui Lv, Luyun He, Nian Liu and Benyu Liu
    Citation: Cellular & Molecular Biology Letters 2025 30:86
    Content type: Research Article Published on:

  4. Coronary heart disease (CHD) remains a global health threat. As antiplatelet therapy constitutes the cornerstone of CHD management, ticagrelor has been universally endorsed as a first-line agent in major clini...

    Authors: Jiajie Chen, Guifeng Xu, Zhipeng Xie, Shaoxia Xie, Wenwei Luo, Shilong Zhong and Weihua Lai
    Citation: Cellular & Molecular Biology Letters 2025 30:84
    Content type: Research Article Published on:

  5. Yes-associated protein (YAP) and its paralog, transcriptional coactivator with PDZ-binding motif (TAZ), are critical effectors of the Hippo pathway, as well as other biochemical and biophysical signals. Throug...

    Authors: Zhenxiong Zhang, Peiheng He, Li Yang, Jun Gong, Renyi Qin and Min Wang
    Citation: Cellular & Molecular Biology Letters 2025 30:83
    Content type: Mini Review Published on:

  6. The skin is subjected to constant mechanical stress in both healthy and wounded states. Macrophages play crucial roles in skin homeostasis and in all stages of the wound healing process. However, the effects o...

    Authors: Qian Wei, Fangzhou Du, Jinjiang Cui, Jiangen Xu, Yuchen Xia, Shikai Li, Qiong Deng, Xiaoyu Xu, Jingzhong Zhang and Shuang Yu
    Citation: Cellular & Molecular Biology Letters 2025 30:82
    Content type: Research Article Published on:

  7. Mammalian arachidonic acid lipoxygenases (ALOXs) have previously been implicated in the pathogenesis of inflammatory disease, and pro- as well as anti-inflammatory activities have been reported. The human geno...

    Authors: Florian Reisch, Marjann Schäfer, Dominika Labuz, Halina Machelska, Sabine Stehling, Gerhard P. Püschel, Michael Rothe, Dagmar Heydeck and Hartmut Kuhn
    Citation: Cellular & Molecular Biology Letters 2025 30:81
    Content type: Research Article Published on:

  8. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for coronavirus disease 2019 (COVID-19), disrupts the alveolar epithelial barrier and exacerbates airway inflammation, leading to acute...

    Authors: Flavio Alvarez, Guilherme Dias de Melo, Florence Larrous, Lauriane Kergoat, Batiste Boëda, Vincent Michel, Danielle Seilhean, Magali Tichit, David Hing, David Hardy, Etienne Kornobis, Hervé Bourhy, Nicolas Wolff and Célia Caillet-Saguy
    Citation: Cellular & Molecular Biology Letters 2025 30:80
    Content type: Brief Report Published on:

  9. The epithelial sodium channel (ENaC) situated in the apical membrane of alveolar epithelial type 2 (AT2) cells is beneficial to edematous fluid reabsorption in acute lung injury (ALI). Recently, mesenchymal st...

    Authors: Shuning Xin, Yan Ding, Tong Yu, Yunmei Fu, Yong Cui and Hongguang Nie
    Citation: Cellular & Molecular Biology Letters 2025 30:79
    Content type: Research Article Published on:

  11. The serine/threonine kinase Akt is crucial for cell physiology and can also contribute to pathology if its activation and regulation is disturbed. This kinase phosphorylates several substrates involved in mech...

    Authors: Valentina Serratore, Maria Lucibello, Donatella Malanga, Giuseppe Viglietto and Carmela De Marco
    Citation: Cellular & Molecular Biology Letters 2025 30:77
    Content type: Review Published on:

  12. Triple-negative breast cancer (TNBC), particularly in patients with metastasis, is associated with limited treatment options and shorter survival times. In this study, through library screening and animal expe...

    Authors: Jun Xu, Xiaoyu Yang, Peng Shu, Wei Wang, Haibo Wu and Zhe Wang
    Citation: Cellular & Molecular Biology Letters 2025 30:76
    Content type: Research Article Published on:

  13. Benzodiazepines (Diazepam) and related Z-drugs (Zolpidem), henceforth referred to as BZDRs, are widely used for clinical treatment of insomnia and anxiety disorders. BZDRs act on GABA type A receptors to inhib...

    Authors: Wei-Chung Vivian Yang, Yen-Yi Lin, Jeak Ling Ding, Chin-Sheng Hung, Phung-Anh Nguyen, Bo-Xiang Zhang, Tsung-Han Hsieh and Shu-Chun Chang
    Citation: Cellular & Molecular Biology Letters 2025 30:75
    Content type: Research Article Published on:

  14. Resveratrol (RSV) is one of the most studied and used biomolecules, for which many pharmacological effects targeting multiple tissues have been described. However, a common underlying mechanism driving its ful...

    Authors: Ana Soriano-Lerma, Victoria Sánchez-Martín, Javier Murciano-Calles, Matilde Ortiz-González, María J. Tello-López, Virginia Pérez-Carrasco, Ángel Linde-Rodríguez, Inmaculada Ramírez-Macías, Irene Gómez-Pìnto, Inmaculada López-Aliaga, Miguel Soriano and Jose A. Garcia Salcedo
    Citation: Cellular & Molecular Biology Letters 2025 30:74
    Content type: Brief Report Published on:

  15. Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by multilayered dysregulation of immune cell homeostasis, spanning B cell effector dysfunction, T follicular helper (Tfh) cell h...

    Authors: YuXian Wu, Wangzheqi Zhang, Yan Liao, Ting Sun, Yang Liu and Yaoyang Liu
    Citation: Cellular & Molecular Biology Letters 2025 30:73
    Content type: Review Published on:

  16. Interstitial fibrosis after acute kidney injury is an ongoing pathological process of chronic inflammatory injury and repair. Macrophages participate in renal inflammation, repair and fibrosis by continuously ...

    Authors: Na Gong, Wenjuan Wang, Yifei Fu, Xumin Zheng, Xinru Guo, Yuhao Chen, Yan Chen, Shengchun Zheng and Guangyan Cai
    Citation: Cellular & Molecular Biology Letters 2025 30:72
    Content type: Review Published on:

  17. Gastric cancer (GC) is a significant challenge for global health. Neutrophils, the predominant white blood cells in the innate immune system, are increasingly becoming known as potential contributors to either...

    Authors: Yansong Qin, Yunmei Liu, Peixin Dong, Wen-Bin Zou, Zhaoshen Li and Lei Huang
    Citation: Cellular & Molecular Biology Letters 2025 30:71
    Content type: Review Published on:

  18. During the transformation of viral hepatitis into hepatocellular carcinoma (HCC), oxidative stress levels increase significantly, leading to tissue damage and chronic inflammation. HCC is characterized by spat...

    Authors: Huimin Yuan, Jia Liu, Ruochen Xu, Keshan Yang, Ruiyang Qu, Shuai Liu, Yonghui Zhang and Ming Xiang
    Citation: Cellular & Molecular Biology Letters 2025 30:70
    Content type: Review Published on:

  19. Pulmonary infections are common respiratory diseases caused by a variety of pathogens, some of which can lead to epidemics. When they progress to acute lung injury or acute respiratory distress syndrome, the m...

    Authors: Fei Hou, Nan Shi, Haoran Yuan, Bingyi Li, Junjie Xiao, Kun Xiao and Lixin Xie
    Citation: Cellular & Molecular Biology Letters 2025 30:69
    Content type: Mini Review Published on:

  21. Osteoarthritis (OA) is a chronic joint disease characterized by cartilage degeneration with unclear pathogenic mechanism. This study aims to discuss the regulatory role of cancerous inhibitor of protein phosph...

    Authors: Jingyue Su, Xuying Sun, Xin Chen, Kang Wei, Danni Luo, Shengwu Yang, Chunwu Zhang, Jian Xu and Zhenhan Deng
    Citation: Cellular & Molecular Biology Letters 2025 30:67
    Content type: Research Article Published on:

  22. Disulfidptosis represents a newly identified form of regulated cell death (RCD) distinct from other well-established RCD pathways. It occurs during periods of glucose starvation, specifically when intracellula...

    Authors: Yingchao Liu, Sainan Li, Yunyi Wu, Ping Zhang, Yanhua Yu, Xi Chen, Lingyan Yu, Xinyi Yang, Huanjuan Li, Cuiyun Wu, Jing Du and Yanchun Li
    Citation: Cellular & Molecular Biology Letters 2025 30:66
    Content type: Review Published on:

  23. Gastric cancer (GC) is one of the most prevalent digestive tract malignancies, with metastasis being a major contributor to poor prognosis in patients. Fibronectin type III domain-containing 3B (FNDC3B) plays ...

    Authors: Yuying Zhang, Lingyu Ran, Yuying Liu, Wei Li, Ai Ran, Haiping Li, Bo Huang, Junwu Ren, Hao Ning, Qiang Ma, Xiaolin Wang, Feifei Yang, Xiaojuan Pan, Ce Liang, Shimin Wang, Changhong Qin…
    Citation: Cellular & Molecular Biology Letters 2025 30:65
    Content type: Research Article Published on:

  24. Cetuximab resistance severely restricts its effectiveness in the treatment of patients with metastatic colorectal cancer (CRC). Previous studies have predominantly focused on the genetic level, with scant atte...

    Authors: Shiyun Chen, Zhaoli Tan, Yanli Lin, Fang Pang, Xiaojie Wu, Xiang Li, Yumeng Cui, Weiling Man, Ying Li, Yanghua Li, Lu Han, Miaomiao Gou, Zhikuan Wang, Guanghai Dai and Youliang Wang
    Citation: Cellular & Molecular Biology Letters 2025 30:64
    Content type: Research Article Published on:

  25. Ewing sarcomas (ESs) are aggressive paediatric tumours of bone and soft tissues afflicting children and adolescents. Despite current therapies having improved the 5-year survival rate to 70% in patients with l...

    Authors: Lidia Chellini, Arianna Del Verme, Veronica Riccioni and Maria Paola Paronetto
    Citation: Cellular & Molecular Biology Letters 2025 30:63
    Content type: Research Article Published on:

  26. tRNA-derived fragments (tRFs) have emerged as significant noncoding RNAs in cancer biology; however, their roles and mechanisms in triple-negative breast cancer (TNBC) remain inadequately characterized.

    Authors: Jingjing Lu, Yangbai Sun, Xiufen Zhang, Bujie Xu, Ping Zhu, Linzi Zeng, Xue Wang, Wei Zhu and Ping Zhou
    Citation: Cellular & Molecular Biology Letters 2025 30:62
    Content type: Research Article Published on:

  27. Colorectal cancer (CRC) is a prevalent and highly malignant neoplasm on a global scale, ranking as the second most widespread cause of cancer-associated death. Long noncoding RNAs (lncRNAs) control tumorigenic...

    Authors: Daoquan Fang, Qian Feng, Baojian Zhou, Yangyang Liu, Yichu Lian, Yihui Zhang, Dichen Yang, Xintong Liu, Xiaomeng Shi, Wuhua Ni and Lei Jiang
    Citation: Cellular & Molecular Biology Letters 2025 30:61
    Content type: Research Article Published on:

  28. Sepsis-induced acute lung injury (ALI) is a clinical condition with high morbidity and mortality, and impaired endothelial function is the main pathological characteristic. As a member of DNA demethylases, ten...

    Authors: Hongxue Fu, Bin Gao, Xin Zhou, Yingting Hao, Chang Liu, Ailin Lan, Jingyi Tang and Fachun Zhou
    Citation: Cellular & Molecular Biology Letters 2025 30:60
    Content type: Research Article Published on:

  29. Platinum-based chemotherapy is commonly used to treat non-small cell lung cancer (NSCLC); however, innate and acquired resistance is clinically seen in many patients. Hence, a combinatorial approach with novel...

    Authors: Ji Hae Lee, Seung Hee Seo, Jaegal Shim, Yong-Nyun Kim and Kyungsil Yoon
    Citation: Cellular & Molecular Biology Letters 2025 30:59
    Content type: Research Article Published on:

  30. Testicular aging has profound effects on spermatogenesis, sperm function, and the spermatogenic microenvironment, contributing to reduced male fertility. However, the precise molecular mechanisms by which mito...

    Authors: Jun Yu, Qiuru Huang, Yangbo Fu, Lei He, Cong Shen, Xia Chen, Zhiran Li, Jiaxin Li, Chenyu Wang, Xinda Wang, Binbin Yang, Ziwen Lin, Chen Qiao, Xiaofang Tan, Xiaoqing Yang, Hao Chen…
    Citation: Cellular & Molecular Biology Letters 2025 30:58
    Content type: Research Article Published on:

  31. Acute pancreatitis (AP) is a sterile inflammation, and 10–20% of cases can progress to severe acute pancreatitis (SAP), which seriously threatens human life and health. Neutrophils and their extracellular trap...

    Authors: Qiang Wang, Xiao Zhang, Chenglong Han, Zhenyi Lv, Yi Zheng, Xuxu Liu, Zhiwei Du, Tianming Liu, Dongbo Xue, Tao Li and Liyi Wang
    Citation: Cellular & Molecular Biology Letters 2025 30:57
    Content type: Research Article Published on:

  32. Hepatocellular carcinoma (HCC) is the sixth most prevalent cancer globally and the third leading cause of cancer-related mortality. Protein ubiquitination and deubiquitination play vital roles in human cancers...

    Authors: Qingwei Zhu, Zibo Yuan, Qiang Huo, Qiliang Lu, Qingsong Wu, Junwei Guo, Wen Fu, Ying Lu, Lei Zhong, Wenzhong Shang, Di Cui, Shuangshuang Li, Xin Liu, Kangsheng Tu, Dongsheng Huang, Qiuran Xu…
    Citation: Cellular & Molecular Biology Letters 2025 30:56
    Content type: Research Article Published on:

  33. Ras homolog gene family-guanosine triphosphatases (Rho-GTPases), key molecular switches regulating cytoskeletal dynamics and cellular signaling, play a pivotal role in viral infections by modulating critical p...

    Authors: Beibei Zhang, Shuli Li, Juntao Ding, Jingxia Guo, Zhenghai Ma and Hong Duan
    Citation: Cellular & Molecular Biology Letters 2025 30:55
    Content type: Review Published on:

  34. Age-related macular degeneration (AMD) is an eye disease that can lead to legal blindness and vision loss. In its advanced stages, it is classified into dry and neovascular AMD. In neovascular AMD, the formati...

    Authors: Janusz Blasiak, Elzbieta Pawlowska, Hanna Helotera, Maksim Ionov, Marcin Derwich and Kai Kaarniranta
    Citation: Cellular & Molecular Biology Letters 2025 30:54
    Content type: Review Published on:

  35. Sarcopenia, characterized by a progressive loss of skeletal muscle mass and function, is associated with the accumulation of senescent muscle stem cells, which impair muscle regeneration and contributes to the...

    Authors: Sujin Kim, Bonsang Gu, Chan-Young So, Keren Esther Kristina Mantik, Seung-Hyun Jung, Sohee Moon, Dong-Ho Park, Hyo-Bum Kwak, Jinkyung Cho, Eun-Jeong Cho, Jae-Seon Lee and Ju-Hee Kang
    Citation: Cellular & Molecular Biology Letters 2025 30:53
    Content type: Research Article Published on:

  36. Arginine auxotrophy has been reported in a subset of cancers with inherently defective de novo arginine synthesis. However, the use of arginine deprivation therapy seems to be unequally effective, partially ow...

    Authors: Vu T. A. Vo, Le Nhat Tran, Thu Thanh Bui, Han-Woong Lee and Yangsik Jeong
    Citation: Cellular & Molecular Biology Letters 2025 30:52
    Content type: Brief Report Published on:

  39. Systemic lupus erythematosus (SLE), influenced by gut microbiota dysbiosis, is characterized by autoimmune and inflammatory responses. Human umbilical cord-derived mesenchymal stem cell (hUC-MSC) transplantati...

    Authors: Quanren Pan, Fengbiao Guo, Jiaxuan Chen, Haimin Huang, Yanyan Huang, Shuzhen Liao, Zengzhi Xiao, Xi Wang, Liuyong You, Lawei Yang, Xuemei Huang, Haiyan Xiao, Hua-Feng Liu and Qingjun Pan
    Citation: Cellular & Molecular Biology Letters 2025 30:49
    Content type: Research Article Published on:

  40. Prostate cancer (PCa) is the second most common cancer affecting men globally, especially those aged 50 years and above. Despite substantial progress in terms of both prognosis and therapy, PCa remains a signi...

    Authors: Daniela Claudia Maresca, Evelina La Civita, Benedetta Romano, Maria Rosaria Ambrosio, Fabio Somma, Tania Wyss, Bernardo Rocco, Valentina Rubino, Luigi Cari, Philippe Krebs, Antonio Rodriguez-Calero, Matteo Ferro, Sara Trabanelli, Camilla Jandus, Felice Crocetto, Angela Ianaro…
    Citation: Cellular & Molecular Biology Letters 2025 30:48
    Content type: Research Article Published on:

  41. Tolerogenic dendritic cells (toDCs) are critical for maintaining immune homeostasis and preventing autoimmune disease development, such as type 1 diabetes (T1D). We have previously shown that DCs of non-obese ...

    Authors: Farhan Ullah Khan, Puregmaa Khongorzul, Denis Gris and Abdelaziz Amrani
    Citation: Cellular & Molecular Biology Letters 2025 30:47
    Content type: Research Article Published on:

  43. Osteosarcoma is the most prevalent primary malignant bone tumor affecting pediatric and adolescent individuals. However, despite the passage of three decades, there has been no notable enhancement in the overa...

    Authors: Junkai Chen, Hongbo Li, Qinglin Jin, Xiaoguang Li, Yiwen Zhang, Jingnan Shen, Gang Huang, Junqiang Yin, Changye Zou, Xinyu Li, Xin He, Xianbiao Xie and Tiao Lin
    Citation: Cellular & Molecular Biology Letters 2025 30:45
    Content type: Research Article Published on:

  44. Despite exhaustive research efforts, integrated genetic and epigenetic mechanisms contributing to tobacco-induced initiation and progression of lung cancers have yet to be fully elucidated. In particular, limi...

    Authors: Sichuan Xi, Jigui Shan, Xinwei Wu, Haitao Wang, Mary R. Zhang, Shakirat Oyetunji, Hong Xu, Zuoxiang Xiao, Tuana Tolunay, Shamus R. Carr, Chuong D. Hoang and David S. Schrump
    Citation: Cellular & Molecular Biology Letters 2025 30:44
    Content type: Research Article Published on:

  46. Ischemia–reperfusion (I/R) injury describes the pathological process wherein tissue damage, initially caused by insufficient blood supply (ischemia), is exacerbated upon the restoration of blood flow (reperfus...

    Authors: Lingxuan Tang, Wangzheqi Zhang, Yan Liao, Weijie Wang, Xiaoming Deng, Changli Wang and Wenwen Shi
    Citation: Cellular & Molecular Biology Letters 2025 30:42
    Content type: Review Published on:

  47. The incidence of atherosclerosis markedly rises following menopause. Our previous findings demonstrated that elevated follicle-stimulating hormone (FSH) levels in postmenopausal women accelerate atherosclerosi...

    Authors: Ping Li, Yixiao Xiang, Jinzhi Wei, Xingyan Xu, Jiale Wang, Haowei Yu, Xiaosa Li, Huiping Lin and Xiaodong Fu
    Citation: Cellular & Molecular Biology Letters 2025 30:41
    Content type: Research Article Published on:

  48. Lung cancer is the most frequently diagnosed malignancy and the leading cause of cancer-related mortality worldwide. Similar to other solid tumors, the development of non-small cell lung cancer (NSCLC) is beli...

    Authors: Zhipeng Wang, Yan Wu, Ziqi Ding, Xinru Xiao, Yanhua Huang, Zhiguang Liu and Qian Zhang
    Citation: Cellular & Molecular Biology Letters 2025 30:40
    Content type: Research Article Published on:

    The Correction to this article has been published in Cellular & Molecular Biology Letters 2025 30:78

  49. Although hepatic ischemia–reperfusion injury (IRI) frequently occurs during liver resection and transplantation, the underlying mechanisms remain incompletely understood. Through high-throughput sequencing, we...

    Authors: Dengliang Lei, Yihua Wang, Shanshan Li, Song Xiang, Yunhai Luo, Ping Yan, Fang Luo, Zuotian Huang and ZhongJun Wu
    Citation: Cellular & Molecular Biology Letters 2025 30:39
    Content type: Research Article Published on:

  50. Fibroblast-like synoviocytes (FLS) are crucial for maintaining synovial homeostasis. SMYD5, a member of the histone lysine methyltransferase subfamily SMYDs, is involved in many pathological processes. This st...

    Authors: Chenxi Xiao, Zhenghua Su, Jialin Zhao, Subei Tan, Mengting He, Yuhui Li, Jiayao Liu, Jie Xu, Yajie Hu, Zhongzheng Li, Chunxiang Fan and Xinhua Liu
    Citation: Cellular & Molecular Biology Letters 2025 30:38
    Content type: Research Article Published on:

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Cellular & Molecular Biology Letters

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