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  1. Pulmonary hypertension (PH) is a progressive disease characterized by pulmonary vascular remodeling. Increasing evidence indicates that endothelial-to-mesenchymal transition (EndMT) in pulmonary artery endothe...

    Authors: Kang Kang, Jingjing Xiang, Xingshi Zhang, Yuting Xie, Mengting Zhou, Le Zeng, Junhao Zhuang, Jiahao Kuang, Yuanyuan Lin, Bozhe Hu, Qianmin Xiong, Qing Yin, Qiang Su, Xiaoyun Liao, Jun Wang, Yanqin Niu…
    Citation: Cellular & Molecular Biology Letters 2024 29:69
    Content type: Brief Report Published on:

  2. Members of the nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing (NLRP) family regulate various physiological and pathological processes. However, none have been shown ...

    Authors: Li-Ya Shi, Yang Wang, Yan-Jie Yang, Qian Li, Zhi-Xia Yang, Li-Hua Sun, Fu-Qiang Luo, Yu-hao He, Shu-Ping Zhang, Ning Su, Jia-Qi Liu, Ye He, Yi-Chun Guan, Zhao-Lian Wei, Yun-Xia Cao and Dong Zhang
    Citation: Cellular & Molecular Biology Letters 2024 29:68
    Content type: Research Article Published on:

  3. It is generally accepted that endothelial cells (ECs), primarily rely on glycolysis for ATP production, despite having functional mitochondria. However, it is also known that ECs are heterogeneous, and their p...

    Authors: Patrycja Kaczara, Izabela Czyzynska-Cichon, Edyta Kus, Anna Kurpinska, Mariola Olkowicz, Kamila Wojnar-Lason, Marta Z. Pacia, Olena Lytvynenko, Myriam Baes and Stefan Chlopicki
    Citation: Cellular & Molecular Biology Letters 2024 29:67
    Content type: Brief Report Published on:

  5. The engineered clustered regularly interspaced short palindromic repeats (CRISPR)–CRISPR-associated protein (Cas) system is currently widely applied in genetic editing and transcriptional regulation. The catal...

    Authors: Ziqi He, Caitao Dong, Tianbao Song, Jiawei Zhou, Tao Xu, Ruyuan He and Sheng Li
    Citation: Cellular & Molecular Biology Letters 2024 29:65
    Content type: Research Article Published on:

  6. Osteoarthritis (OA), known as one of the most common types of aseptic inflammation of the musculoskeletal system, is characterized by chronic pain and whole-joint lesions. With cellular and molecular changes i...

    Authors: Shicheng Jia, Rongji Liang, Jiayou Chen, Shuai Liao, Jianjing Lin and Wei Li
    Citation: Cellular & Molecular Biology Letters 2024 29:64
    Content type: Mini Review Published on:

  7. Endometrial cancer (EC) is one of the most common gynecological cancers. Herein, we aimed to define the role of specific myosin family members in EC because this protein family is involved in the progression o...

    Authors: Yibin Lin, Xiao Chen, Linping Lin, Benhua Xu, Xiaofeng Zhu and Xian Lin
    Citation: Cellular & Molecular Biology Letters 2024 29:63
    Content type: Research Article Published on:

  8. Enhancing angiogenesis may be an effective strategy to promote functional recovery after ischemic stroke. Inflammation regulates angiogenesis. Microglia are crucial cells that initiate inflammatory responses a...

    Authors: Ting Chen, Xin Huang, Yi-Xuan Zhao, Zhi-wen Zhou and Wen-sheng Zhou
    Citation: Cellular & Molecular Biology Letters 2024 29:62
    Content type: Brief Report Published on:

  9. Macrophage proinflammatory activation contributes to the pathology of severe acute pancreatitis (SAP) and, simultaneously, macrophage functional changes, and increased pyroptosis/necrosis can further exacerbat...

    Authors: Yiqiu Peng, Yuxi Yang, Yingying Li, Tingjuan Shi, Ning Xu, Ruixia Liu, Yingyi Luan, Yongming Yao and Chenghong Yin
    Citation: Cellular & Molecular Biology Letters 2024 29:61
    Content type: Research Article Published on:

  10. Cancer therapeutic resistance remains a significant challenge in the pursuit of effective treatment strategies. Circular RNAs (circRNAs), a class of non-coding RNAs, have recently emerged as key regulators of ...

    Authors: Ting Wang, Mengjie He, Xudong Zhang, Zhixun Guo, Pinghan Wang and Fangyi Long
    Citation: Cellular & Molecular Biology Letters 2024 29:60
    Content type: Mini Review Published on:

  11. Skeletal muscle is the largest metabolic organ of the human body. Maintaining the best quality control and functional integrity of mitochondria is essential for the health of skeletal muscle. However, mitochon...

    Authors: Yuhang Lei, Mailin Gan, Yanhao Qiu, Qiuyang Chen, Xingyu Wang, Tianci Liao, Mengying Zhao, Lei Chen, Shunhua Zhang, Ye Zhao, Lili Niu, Yan Wang, Li Zhu and Linyuan Shen
    Citation: Cellular & Molecular Biology Letters 2024 29:59
    Content type: Mini Review Published on:

  12. Non-small cell lung cancer (NSCLC), characterized by low survival rates and a high recurrence rate, is a major cause of cancer-related mortality. Aberrant activation of the PI3K/AKT/mTOR signaling pathway is a...

    Authors: Xiao-Qian Li, Xiao-Ju Cheng, Jie Wu, Kai-Feng Wu and Tie Liu
    Citation: Cellular & Molecular Biology Letters 2024 29:58
    Content type: Research Article Published on:

  13. In tomato (Solanum lycopersicum), the ripening of fruit is regulated by the selective expression of ripening-related genes, and this procedure is controlled by transcription factors (TFs). In the various plant-sp...

    Authors: Changxia Li, Xuemei Hou, Zongxi Zhao, Huwei Liu, Panpan Huang, Meimei Shi, Xuetong Wu, Rong Gao, Zhiya Liu, Lijuan Wei, Yihua Li and Weibiao Liao
    Citation: Cellular & Molecular Biology Letters 2024 29:57
    Content type: Brief Report Published on:

  14. During growth phase, antlers exhibit a very rapid rate of chondrogenesis. The antler is formed from its growth center reserve mesenchyme (RM) cells, which have been found to be the derivatives of paired relate...

    Authors: Pengfei Hu, Guokun Zhang, Hengxing Ba, Jing Ren, Jiping Li, Zhen Wang and Chunyi Li
    Citation: Cellular & Molecular Biology Letters 2024 29:56
    Content type: Research Article Published on:

  15. Viral myocarditis (VMC) is a disease resulting from viral infection, which manifests as inflammation of myocardial cells. Until now, the treatment of VMC is still a great challenge for clinicians. Increasing s...

    Authors: Ya Wang, Zhengyang Zhang, Hui Li, Min Wang, Yuting Qiu and Lili Lu
    Citation: Cellular & Molecular Biology Letters 2024 29:55
    Content type: Research Article Published on:

  16. The trafficking of cargoes from endosomes to the trans-Golgi network requires numerous sequential and coordinated steps. Cargoes are sorted into endosomal-derived carriers that are transported, tethered, and fuse...

    Authors: Jérôme Gilleron, Abderrahman Chafik, Sandra Lacas-Gervais, Jean-François Tanti and Mireille Cormont
    Citation: Cellular & Molecular Biology Letters 2024 29:54
    Content type: Research Article Published on:

  17. Reactive oxygen species (ROS) serve as typical metabolic byproducts of aerobic life and play a pivotal role in redox reactions and signal transduction pathways. Contingent upon their concentration, ROS product...

    Authors: Qiangan Jing, Chaoting Zhou, Junyu Zhang, Ping Zhang, Yunyi Wu, Junyu Zhou, Xiangmin Tong, Yanchun Li, Jing Du and Ying Wang
    Citation: Cellular & Molecular Biology Letters 2024 29:53
    Content type: Review Published on:

  18. T cell immunity is central to contemporary cancer and autoimmune therapies, encompassing immune checkpoint blockade and adoptive T cell therapies. Their diverse characteristics can be reprogrammed by different...

    Authors: Xiaoying Chen, Shuhan Zhong, Yonghao Zhan and Xuepei Zhang
    Citation: Cellular & Molecular Biology Letters 2024 29:52
    Content type: Mini Review Published on:

  19. Long noncoding RNAs (lncRNAs) play essential roles in the tumorigenesis of gastric cancer. However, the influence of lncRNA methylation on gastric cancer stem cells (GCSCs) remains unclear.

    Authors: Yuan Ci, Yuan Zhang and Xiaobo Zhang
    Citation: Cellular & Molecular Biology Letters 2024 29:51
    Content type: Research Article Published on:

    The Correction to this article has been published in Cellular & Molecular Biology Letters 2024 29:102

  20. Melanoma is the most lethal skin cancer characterized by its high metastatic potential. In the past decade, targeted and immunotherapy have brought revolutionary survival benefits to patients with advanced and...

    Authors: Weisong Li, Chao Zheng, Xi Xu, Yujie Xia, Kai Zhang, Ao Huang, Xinyu Zhang, Yong Zheng, Guofang Chen and Shuyong Zhang
    Citation: Cellular & Molecular Biology Letters 2024 29:50
    Content type: Research Article Published on:

  22. Clustered regularly interspaced short palindromic repeats and associated Cas protein (CRISPR–Cas), a powerful genome editing tool, has revolutionized gene function investigation and exhibits huge potential for...

    Authors: Ying Wang, Yujing Zhai, Mingzhe Zhang, Chunlin Song, Yuqing Zhang and Gang Zhang
    Citation: Cellular & Molecular Biology Letters 2024 29:48
    Content type: Mini Review Published on:

  23. Glucose-6-phosphate dehydrogenase (G6PD) plays an important role in vascular smooth muscle cell (VSMC) phenotypic switching, which is an early pathogenic event in various vascular remodeling diseases (VRDs). H...

    Authors: Ting Zhang, Rui-Jie Cao, Jiang-Ling Niu, Zhi-Huan Chen, Shi-Qing Mu, Tong Cao, Jie-Xin Pang and Li-Hua Dong
    Citation: Cellular & Molecular Biology Letters 2024 29:47
    Content type: Research Article Published on:

  24. Small extracellular vesicles (sEV) are closely associated with the development and metastasis of many types of mammalian cancer. Glycoconjugates are highly expressed on sEV and play important roles in sEV biog...

    Authors: Meixuan Lin, Xiaoqiang Xu, Xiaoman Zhou, Hui Feng, Ruili Wang, Yunyun Yang, Jing Li, Ning Fan, Yazhuo Jiang, Xiang Li, Feng Guan and Zengqi Tan
    Citation: Cellular & Molecular Biology Letters 2024 29:46
    Content type: Brief Report Published on:

  26. Aspartate–glutamate carrier isoform 1 (AGC1) is a carrier responsible for the export of mitochondrial aspartate in exchange for cytosolic glutamate and is part of the malate–aspartate shuttle, essential for th...

    Authors: Nicola Balboni, Giorgia Babini, Eleonora Poeta, Michele Protti, Laura Mercolini, Maria Chiara Magnifico, Simona Nicole Barile, Francesca Massenzio, Antonella Pignataro, Federico M. Giorgi, Francesco Massimo Lasorsa and Barbara Monti
    Citation: Cellular & Molecular Biology Letters 2024 29:44
    Content type: Brief Report Published on:

  27. Circular RNAs (circRNAs) are single-stranded RNAs with covalently closed structures that have been implicated in cancer progression. However, the regulatory mechanisms remain largely unclear. So, the aim of th...

    Authors: Mingming Jin, Tailei Yuan, Kaisai Tian, Jingjing Li, Qingqing Huang, Yongbin Chi and Gang Huang
    Citation: Cellular & Molecular Biology Letters 2024 29:43
    Content type: Research Article Published on:

  28. Elucidating the intricate interactions between viral pathogens and host cellular machinery during infection is paramount for understanding pathogenic mechanisms and identifying potential therapeutic targets. T...

    Authors: Xiangdong Fan, Yitong Zhang, Ruiying Guo, Kuo Yue, Guy Smagghe, Yongyue Lu and Luoluo Wang
    Citation: Cellular & Molecular Biology Letters 2024 29:42
    Content type: Mini Review Published on:

  29. Prominin-1 (CD133) is a cholesterol-binding membrane glycoprotein selectively associated with highly curved and prominent membrane structures. It is widely recognized as an antigenic marker of stem cells and c...

    Authors: Petr Pleskač, Christine A. Fargeas, Renata Veselska, Denis Corbeil and Jan Skoda
    Citation: Cellular & Molecular Biology Letters 2024 29:41
    Content type: Review Published on:

  31. IGF2BP3 functions as an RNA-binding protein (RBP) and plays a role in the posttranscriptional control of mRNA localization, stability, and translation. Its dysregulation is frequently associated with tumorigen...

    Authors: Lei Lv, Qinqin Wei, Jianxiao Zhang, Yitong Dong, Zhenglei Shan, Na Chang, Ye Zhao, Po Bian and Qiyi Yi
    Citation: Cellular & Molecular Biology Letters 2024 29:39
    Content type: Research Article Published on:

  33. DNA mismatch repair (MMR) is a highly conserved pathway that corrects DNA replication errors, the loss of which is attributed to the development of various types of cancers. Although well characterized, MMR fa...

    Authors: Demin Du, Yueyan Yang, Yuanyuan Zhang, Guanxiong Wang, Liying Chen, Xiaowei Guan, Lene Juel Rasmussen and Dekang Liu
    Citation: Cellular & Molecular Biology Letters 2024 29:37
    Content type: Research Article Published on:

  34. Macrophage activation may play a crucial role in the increased susceptibility of obese individuals to acute lung injury (ALI). Dysregulation of miRNA, which is involved in various inflammatory diseases, is oft...

    Authors: Siqi Wu, Wenjing Tang, Ling Liu, Ke Wei, Yin Tang, Jingyue Ma, Hongbin Li and Yichan Ao
    Citation: Cellular & Molecular Biology Letters 2024 29:36
    Content type: Research Article Published on:

  35. Epidemiological evidence suggests that the phenotype of glutathione S-transferase mu 1 (GSTM1), a hepatic high-expressed phase II detoxification enzyme, is closely associated with the incidence of alcohol-related...

    Authors: Tiantian Xu, Yan Pan, Qinchao Ding, Feiwei Cao, Kaixin Chang, Jiannan Qiu, Hui Zhuge, Liuyi Hao, Haibin Wei, Caijuan Si, Xiaobing Dou and Songtao Li
    Citation: Cellular & Molecular Biology Letters 2024 29:35
    Content type: Research Article Published on:

  36. Persistent infection with high-risk human papillomavirus (HR-HPV) is the primary and initiating factor for cervical cancer. With over 200 identified HPV types, including 14 high-risk types that integrate into ...

    Authors: Yan Liu, Zhujun Chao, Wei Ding, Tanfeng Fang, Xinxian Gu, Man Xue, Wei Wang, Rong Han and Wanping Sun
    Citation: Cellular & Molecular Biology Letters 2024 29:34
    Content type: Research Article Published on:

    The Correction to this article has been published in Cellular & Molecular Biology Letters 2024 29:49

  37. Gut microbiota regulates various aspects of human physiology by producing metabolites, metabolizing enzymes, and toxins. Many studies have linked microbiota with human health and altered microbiome configurati...

    Authors: Menatallah Rayan, Tahseen S. Sayed, Ola J. Hussein, Lubna Therachiyil, Zaid H. Maayah, Cristina Maccalli, Shahab Uddin, Jochen H. M. Prehn and Hesham M. Korashy
    Citation: Cellular & Molecular Biology Letters 2024 29:33
    Content type: Mini Review Published on:

  38. RNA-binding proteins (RBPs) are kinds of proteins with either singular or multiple RNA-binding domains (RBDs), and they can assembly into ribonucleic acid–protein complexes, which mediate transportation, editi...

    Authors: Wan‑Jia Qin, Jin-Jin Shi, Ru-Yi Chen, Chang-Yun Li, Yan-Jun Liu, Jian-Fei Lu, Guan-Jun Yang, Jia-Feng Cao and Jiong Chen
    Citation: Cellular & Molecular Biology Letters 2024 29:32
    Content type: Mini Review Published on:

  39. Acute kidney injury (AKI) is a common clinical disorder with complex etiology and poor prognosis, and currently lacks specific and effective treatment options. Mitochondrial dynamics dysfunction is a prominent...

    Authors: Zhixia Song, Yao Xia, Lang Shi, Hongchu Zha, Jing Huang, Xiaohong Xiang, Huiming Li, Hua Huang, Ruchi Yue, Hongtao Wang and Jiefu Zhu
    Citation: Cellular & Molecular Biology Letters 2024 29:31
    Content type: Research Article Published on:

  40. Exosomes are nano-sized membrane extracellular vesicles which can be released from various types of cells. Exosomes originating from inflammatory or injured cells can have detrimental effects on recipient cell...

    Authors: Zeinab Vahidinia, Abolfazl Azami Tameh, Shirin Barati, Melika Izadpanah and Elahe Seyed Hosseini
    Citation: Cellular & Molecular Biology Letters 2024 29:30
    Content type: Mini Review Published on:

  41. Malignant melanoma remains the most lethal form of skin cancer, exhibiting poor prognosis after forming distant metastasis. Owing to their potential tumor-suppressive properties by regulating oncogenes and tum...

    Authors: Lisa Lämmerhirt, Melanie Kappelmann-Fenzl, Stefan Fischer, Paula Meier, Sebastian Staebler, Silke Kuphal and Anja-Katrin Bosserhoff
    Citation: Cellular & Molecular Biology Letters 2024 29:29
    Content type: Research Article Published on:

  42. Bladder cancer (BCa) ranks among the predominant malignancies affecting the urinary system. Cisplatin (CDDP) remains a cornerstone therapeutic agent for BCa management. Recent insights suggest pivotal roles of...

    Authors: Congjie Xu, Jiaquan Zhou, Xiaoting Zhang, Xinli Kang, Shuan Liu, Mi Song, Cheng Chang, Youtu Lin and Yang Wang
    Citation: Cellular & Molecular Biology Letters 2024 29:28
    Content type: Research Article Published on:

  43. The R-RAS2 is a small GTPase highly similar to classical RAS proteins at the regulatory and signaling levels. The high evolutionary conservation of R-RAS2, its links to basic cellular processes and its role in...

    Authors: Antea Talajić, Kristina Dominko, Marija Lončarić, Andreja Ambriović-Ristov and Helena Ćetković
    Citation: Cellular & Molecular Biology Letters 2024 29:27
    Content type: Research Article Published on:

  44. The peroxisome is a dynamic organelle with variety in number, size, shape, and activity in different cell types and physiological states. Recent studies have implicated peroxisomal homeostasis in ferroptosis s...

    Authors: Daheng Zheng, Fei Li, Shanshan Wang, Pu-Ste Liu and Xin Xie
    Citation: Cellular & Molecular Biology Letters 2024 29:26
    Content type: Brief Report Published on:

  45. Cervical cancer (CCa) is the fourth most common cancer among females, with high incidence and mortality rates. Circular RNAs (circRNAs) are key regulators of various biological processes in cancer. However, th...

    Authors: Chunyu Zhang, Li Yuan, Qiaojian Zou, Caixia Shao, Yan Jia, Jiaying Li, Yan Liao, Xueyuan Zhao, Weijia Wen, Xu Jing, Guofen Yang, Wei Wang, Hongye Jiang and Shuzhong Yao
    Citation: Cellular & Molecular Biology Letters 2024 29:25
    Content type: Research Article Published on:

  46. Chronic nonhealing wounds remain a considerable challenge in clinical treatment due to excessive inflammation and impeded reepithelialization and angiogenesis. Therefore, the discovery of novel prohealing agen...

    Authors: Chao Li, Yuxin Xiong, Zhe Fu, Yuxin Ji, Jiayi Yan, Yan Kong, Ying Peng, Zeqiong Ru, Yubing Huang, Yilin Li, Ying Yang, Li He, Jing Tang, Ying Wang and Xinwang Yang
    Citation: Cellular & Molecular Biology Letters 2024 29:24
    Content type: Research Article Published on:

  47. For decades, lactate has been considered a byproduct of glycolysis. The lactate shuttle hypothesis shifted the lactate paradigm, demonstrating that lactate not only plays important roles in cellular metabolism...

    Authors: Junyong Wang, Ziyi Wang, Qixu Wang, Xiao Li and Yaping Guo
    Citation: Cellular & Molecular Biology Letters 2024 29:23
    Content type: Mini Review Published on:

  48. There is a high morbidity and mortality rate in mechanical trauma (MT)-induced hepatic injury. Currently, the molecular mechanisms underlying liver MT are largely unclear. Exploring the underlying mechanisms a...

    Authors: Rui Shi, Zhenhua Liu, Huan Yue, Man Li, Simin Liu, Dema De, Runjing Li, Yunan Chen, Shuli Cheng, Xiaoming Gu, Min Jia, Jun Li, Juan Li, Shumiao Zhang, Na Feng, Rong Fan…
    Citation: Cellular & Molecular Biology Letters 2024 29:22
    Content type: Research Article Published on:

  49. Septic cardiomyopathy (SCM), a common cardiovascular comorbidity of sepsis, has emerged among the leading causes of death in patients with sepsis. SCM’s pathogenesis is strongly affected by mitochondrial metab...

    Authors: Yukun Li, Jiachi Yu, Ruibing Li, Hao Zhou and Xing Chang
    Citation: Cellular & Molecular Biology Letters 2024 29:21
    Content type: Research Article Published on:

  50. Cisplatin (DDP) is a widely used chemotherapy drug for advanced cervical cancer (CC), but resistance poses a significant challenge. While miR-4739 has been implicated in tumor development, its specific role in...

    Authors: Yuling Li, Zhengtong Zhou, Jinfeng Qu, Peiling Gong, Yuyan Wei and Yaping Sun
    Citation: Cellular & Molecular Biology Letters 2024 29:20
    Content type: Research Article Published on:

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Cellular & Molecular Biology Letters

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