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On the role of ball and chain interactions in recovery from the inactivation of the shaker potassium channel
Cellular & Molecular Biology Letters volume 13, pages 526–534 (2008)
Abstract
We describe a new factor in the recovery from inactivation in the ball and chain model. We propose a model in which the tension from the chain may help pull the ball away from its binding site, reducing the duration of the inactivation period. A corresponding model was built and analysed.
Abbreviations
- kT:
-
Boltzmann constant times environment temperature
- RHS:
-
right-hand side
References
Armstrong, C.M. and Bezanilla F. Inactivation of the sodium channel, part II-gating current experiments. J. Gen. Physiol. 70 (1977) 567–590.
Goldin, A.L. Mechanisms of sodium channel inactivation. Curr. Op. Neurobiol. 13 (2003) 284–290.
Hoshi T., Zagotta, W.N. and Aldrich, R.W. Biophysical and molecular mechanisms of shaker potassium channel inactivation. Science 250 (1990) 533–538.
Zagotta, W.N., Hoshi, T. and Aldrich, R.W. Restoration of inactivation in mutants of shaker potassium channels by a peptide derived from ShB. Science 250 (1990) 568–571.
Murrell-Lagnado, R.D. and Aldrich, R.W. Interactions of amino terminal domains of shaker K channels with a pore blocking site studied with synthetic peptides. J. Gen. Physiol. 102 (1993) 949–975.
Demo, S.D. and Yellen, G. The inactivation gate of the shaker K+ channel behaves like an open-channel blocker. Neuron 7 (1991) 743–753.
Gomez-Lagunas, F. and Armstrong, C.M. The Relation between ion permeation and recovery from inactivation of ShakerB K+ channels. Biophys. J. 67 (1994) 1806–1815.
Haak, R.A., Kleinhans, F.W. and Ochs, S. The viscosity of mammalian nerve axoplasm measured by electron spin resonance. J. Physiol. 263 (1976) 115–137.
Collins, R.M.W. Physics of potassium ion channel inactivation in neurons. Am. J. Undergr. Res. 3 (2004) 27–35.
Małysiak, K., Borys, P. and Grzywna, Z.J. On the ball and chain model by simple and hyperbolic diffusion-an analytical approach. Acta Phys. Pol. B 38 (2007) 1865–1879.
Krasilnikov, O.V., Rodrigues, C.G. and Bezrukov, S.M. Single polymer molecules in a protein nanopore in the limit of a strong polymer-pore attraction. Phys. Rev. Lett. 97 (2006) 018301-1–018301-4, DOI:10.1103/PhysRevLett.97.018301.
Rubinstein, M. and Colby, R.H. Polymer Physics, Oxford University Press, New York, 2003, 49–331.
Gedde, U.W. Polymer Physics, Kuwler Academic Publishers, Dordrecht, 2001, 107–108.
Ermak, D.L. and McCammon, J.A. Brownian dynamics with hydrodynamic interactions. J. Chem. Phys. 69 (1978) 1352–1360.
Dickinson, E. Brownian dynamics with hydrodynamic interactions: The application to protein diffusional problems. Chem. Soc. Rev. 14 (1985) 421–443.
Liebovitch, L.S., Selector, L.Y. and Kline, R.P. Statistical properties predicted by the ball and chain model of channel inactivation. Biophys. J. 63 (1992) 1579–1585.
Rose, G.D., Geselowitz, A.R., Lesser, G.J., Lee, R.H. and Zehfus, M.H. Hydrophobicity of amino acid residues in globular proteins. Science 229 (1985) 834–838.
Chung, S.H., Allen, T.W., Hoyles, M. and Kuyucak, S. Permeation of ions across the potassium channel: Brownian dynamics studies. Biophys. J. 77 (1999) 2517–2533.
Buscaglia, M., Lapidus, L.J., Eaton, W.A. and Hofrichter, J. Effects of denaturants on the dynamics of loop formation in polypeptides. Biophys. J. 91 (2006) 276–288.
Marko, J.F. and Siggia, E.D. Stretching DNA. Macromolecules 28 (1995) 8759–8770.
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Paper authored by participants of the international conference: International Workshop on Ionic Channels, Szczyrk, Poland, May 27 – June 01, 2007. Publication cost was covered by the organisers of this meeting.
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Borys, P., Grzywna, Z.J. On the role of ball and chain interactions in recovery from the inactivation of the shaker potassium channel. Cell Mol Biol Lett 13, 526–534 (2008). https://doiorg.publicaciones.saludcastillayleon.es/10.2478/s11658-008-0018-5
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DOI: https://doiorg.publicaciones.saludcastillayleon.es/10.2478/s11658-008-0018-5