Fig. 1

Elimination of neutrophils and NETs can significantly improve acute pancreatitis A Scanning electron microscope images of pancreatic tissues in normal control group and AP group. The AP group contains neutrophils and NETs. B Fluorescence photo of neutrophil infiltration and NETs accumulation after treating the AP mouse model with neutrophil neutralizing antibody (anti-LY6G) and NETs inhibitor DNaseI. C The proportion of neutrophils in each field of view of each group. D The proportion of NETs in each field of view of each group (MPO is red, representing neutrophils, pointed to by white arrows; CITH3 is bright green, pointed to by white arrows; yellow represents NETs, pointed to by white arrows). E H&E staining of each group and inflammation score and edema degree score. F Levels of serum amylase and lipase in mice of each group. G Immunohistochemical staining and expression statistics of IL-1β and IFN-γ in each group. Student’s t-test was used for comparison between two groups. *P < 0.05 is considered statistically significant, **^P < 0.01, ***^P < 0.001