Fig. 2
Transcriptomic analysis of the skeletal muscles of young and old rats. A, B (Left) Volcano plots depicting differentially expressed genes (DEG) in the soleus (A) and white gastrocnemius (B) muscles. Red and blue dots indicate significantly upregulated and downregulated genes (adjusted p < 0.001) with a log2 fold change > 2 or < 2, respectively. (Middle) Heatmap of DEGs between skeletal muscles of young and old rats. (Right) Gene Set Enrichment Analysis (GSEA) of enriched pathways between young versus old rats. C Numbers inside the circles indicate the count of upregulated and downregulated genes in the white gastrocnemius and soleus muscles. Commonly upregulated and downregulated genes in both muscles are listed