Fig. 4
From: Circulating innate lymphoid cells are dysregulated in patients with prostate cancer
ILC function is altered in patients with PCa. A, B. Representative example of flow cytometry analysis of ILC2-produced IL-13 (A) and IL-5 (B) in ex vivo PBMCs upon stimulation. C Frequencies of IL-13 and IL-5 positive ILC2s in ex vivo PBMCs from HDs (n = 8) and patients with LG (n = 10) and HG (n = 22) PCa upon stimulation. D, E Representative example of flow cytometry analysis of ILC1-produced TNF-α (D) and IFN-γ (E) in ex vivo PBMCs upon stimulation. F Frequencies of IFN-γ- and TNF-α-positive ILC1s in ex vivo PBMCs from HDs (n = 8) and patients with LG (n = 10) and HG (n = 22) PCa upon stimulation. G Quantification of type 2 cytokines assessed by Legendplex™ analysis in sera of HDs (n = 12) and patients with LG (n = 13) and HG (n = 29) PCa. H Disease-free survival of patients with PCa stratified on the basis of high (red) and low (blue) IL-13 expression. Data shown as mean ± SEM (*p < 0.05; ***p < 0.001; ****p < 0.0001) and analyzed by Wilcoxon and/or one-way ANOVA tests