Fig. 1

CD155 correlates with poor prognosis in OS. A Analysis of the TCGA database reveals that the expression level of CD155 is notably elevated in a range of tumors, in stark contrast to its corresponding normal tissues. B Data analysis from the GEPIA2 database indicates that patients with a high level of CD155 expression have a worse prognosis among cancer patients (the dashed line indicates the 95% confidence interval). C qRT-PCR was employed to assess the mRNA expression level of CD155 in both human OS tissues and their corresponding normal tissues (n = 20). D Western blot experiments were performed to quantitatively evaluate the expression levels of CD155 protein in human OS tissues, as well as their corresponding normal tissues, for the purpose of comparative analysis. E A grayscale analysis on the outcomes presented in D. F The expression of CD155 between hFOB1.19 and OS cell lines detected by qRT-PCR. G Western blot experiment to measure the CD155 protein levels between hFOB1.19 and OS cell lines. H Representative IHC images demonstrating the expression of CD155 in the tumor tissues of OS patients. I Kaplan–Meier survival analysis of OS patients stratified by CD155 expression levels (n = 53, the dashed line indicates the 95% confidence interval). *p < 0.05; **p < 0.01; ***p < 0.001