Fig. 7

Cardiomyocyte-specific overexpression of CDC20 significantly inhibits DOX-induced myocardial injury, while not affecting the antitumor effect of DOX. a Representative images of HE staining in each group (n = 6, bar = 100 μm); b Representative images and statistical data of vacuolization in each group (n = 6, bar = 50 μm); c Representative images and statistical data of Masson staining in each group (n = 6, bar = 100 μm); d Representative images and statistical data of α-SMA staining in each group (n = 6, bar = 50 μm); e Representative images and statistical data of WGA staining in each group (n = 6, bar = 50 μm); f Tumor growth curves of mice in each group (n = 6); g Representative images of tumor in each group; h Statistical data of tumor volume (n = 6); i Statistical data of tumor weight (n = 6); j Representative images and statistical data of PCNA staining in each group (n = 6, bar = 50 μm); k Bax, PCNA, and β-actin expression through western blot (n = 3); l Caspase-3 activity in each group (n = 3). α-SMA: alpha-smooth muscle actin, H&E: hematoxylin and eosin, HW/TL: heart weight/tibia length, PCNA: proliferating cell nuclear antigen, TUNEL: terminal deoxynucleotidyl transferase dUTP nick end labeling, WGA: wheat germ agglutinin. Data presented as mean ± SD. Statistical analysis performed with two-way ANOVA