Fig. 4

Inhibition of CDC20 aggravates DOX‑induced cardiac dysfunction, fibrosis, and apoptosis. a Survival curves in each group; b HW/TL statistics of mice in each group (n = 6–7); c Representative image and statistical data of WGA staining in each group (n = 6, bar = 50 μm); d Representative images and statistics of vacuolization in each group (n = 6–7, bar = 50 μm); e Representative image of HE staining (bar = 50 μm), CD68 staining (bar = 50 μm), and statistical data in each group (n = 6–7); f Representative images and statistical data of Masson staining in each group (n = 6–7, bar = 100 μm); g Representative images and statistical data of Collagen III staining in each group (n = 6–7, bar = 100 μm); h Representative images and statistical data of TUNEL staining in each group (n = 6–7, bar = 20 μm); i Detection of Bax, Bcl-2, and β-actin expression through western blotting (n = 4). DOX: doxorubicin, H&E: Hematoxylin and eosin, HW/TL: heart weight/tibia length, TUNEL: terminal deoxynucleotidyl transferase dUTP nick end labeling, WGA: wheat germ agglutinin. Data presented as mean ± SD. Statistical analysis performed with two-way ANOVA