Fig. 3

Overexpression of CDC20 attenuates DOX-induced cardiac dysfunction, fibrosis, and apoptosis. a Survival curve of mice in each group: b EF% statistics of mice in each group (n = 6–13); c HW/TL statistics of mice in each group (n = 6–13); d Representative image of Masson staining in each group (n = 6–13, bar = 100 μm); e Representative image and statistics of WGA staining in each group (n = 6–13, bar = 50 μm); f HE staining image in each group (n = 6–13, bar = 40 μm); g Representative image and statistical data of vacuolization in each group (n = 6–13, bar = 40 μm); h Representative image and statistical data of TUNEL staining in group (n = 6–13, bar = 40 μm); i Detected expression of Bax, Bcl-2, and β-actin using western blotting (n = 4). DOX: doxorubicin, EF: ejection factor, H&E: Hematoxylin and eosin, HW/TL: heart weight/tibia length, TUNEL: terminal deoxynucleotidyl transferase dUTP nick end labeling, WGA: wheat germ agglutinin. Data presented as mean ± SD. Statistical analysis performed with two-way ANOVA