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Fig. 6 | Cellular & Molecular Biology Letters

Fig. 6

From: tRF-5028c disrupts trophoblast function in recurrent spontaneous abortion by inhibiting CRKL-mediated Rap1 signaling pathway

Fig. 6

tRF-5028c overexpression increased embryo absorption in mice. Pregnant mice were injected with 10 nmol of tRF-5028c mimic (n = 6) or mimic NC (n = 6) on GD5.5, GD8.5, and GD11.5 via tail vein, and euthanized on GD13.5. A Placental tRF-5028c level was detected by qRT-PCR. B, C Analysis of embryo adsorption rate on GD13.5. D Representative images of HE staining in the placentas. The decidua, junctional zone, and labyrinth layers are marked with blue, red and yellow lines, and measured for areas, respectively. E The mRNA levels of invasion-related marker genes (prl3a1, prl3b1, prl2c2, and prl3d1) in placental tissues were assessed using qRT-PCR. F Representative IHC images of expression and localization of CRKL in mice placentas. G, H Placental mRNA and protein levels of CRKL were detected by qRT-PCR and Western blot, respectively. Data presented as mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001

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Cellular & Molecular Biology Letters

ISSN: 1689-1392

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