Fig. 8
From: Repression of ZNFX1 by LncRNA ZFAS1 mediates tobacco-induced pulmonary carcinogenesis
Interactions of ZFAS1 transcripts with DNA methylation and polycomb group proteins. A, B qCLIP analyses of interactions of ZFAS1 with DNMT3A or DNMT3B and DNMT1 as well as EZH2, SUZ12, BMI1 in SAEC and Calu-6 cells exposed to NM or CSC, with or overexpression or knockdown of ZFAS1. CSC and ZFAS1 over-expression induce binding of DNMT3A, DNMT3B, EZH2, SUZ12, and BMI1 but not DNMT1 to ZFAS1 transcripts; knockdown of ZFAS1 diminishes these interactions. Data are mean ± SEM; T-test; n = 3; * p < 0.05; ** p < 0.01