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Fig. 4 | Cellular & Molecular Biology Letters

Fig. 4

From: Repression of ZNFX1 by LncRNA ZFAS1 mediates tobacco-induced pulmonary carcinogenesis

Fig. 4

ZFAS1 functions as an oncogene in lung cancer cells. A Effects of ZFAS1 expression on in vitro proliferation of SAEC and HBEC, as well as Calu-6, H841, H358, and A549 lung cancer cells. ZFAS1 promotes cell growth in normal respiratory epithelia and lung tumor cells. B, C Matrigel invasion assays demonstrate that overexpression of ZFAS1 enhances invasion of Calu-6, H358, A549, and H841 lung cancer cells, whereas siRNA knockdown of ZFAS1 inhibits invasion of control lung cancer cells and attenuates CSC-mediated invasion potential in these cells. *p < 0.05; **p < 0.01. D Growth of H358 and A549 subcutaneous xenografts in nude mice. Volumes of xenografts derived from H358 and A549 cells overexpressing ZFAS1 are significantly larger than control xenografts. E Tumor masses from H358 and A549 xenografts. ZFAS1 overexpression significantly increases the average mass of tumor xenografts. Data are mean ± SEM; T-test; n = 3; * p < 0.05; **p < 0.01

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