Fig. 12
From: Repression of ZNFX1 by LncRNA ZFAS1 mediates tobacco-induced pulmonary carcinogenesis
Mechanistic diagram summarizing mechanisms by which repression of ZNFX1 by ZFAS1 mediates tobacco-induced pulmonary carcinogenesis. CSC activates ZFAS1 in an enhancer-specific manner and induces de novo DNA methylation and polycomb-mediated chromatin remodeling within the ZNFX1 promoter, which subsequently silences this tumor suppressor in NSCLC.