Fig. 8

ADSCs regulate KLF5 / CXCL12 to affect the proliferation, migration and vasculogenic capacity of EPCs. A-D EdU assay measures the cell proliferation of EPCs. Scale bar = 100 μm. E–F, I-J Transwell assay measures the cell migration of EPCs. Scale bar = 100 μm. G-H, K-L Tube formation assay measures the vasculogenic capacity of EPCs. Scale bar = 100 μm. (M Representative images of tissue sections from patients with diabetic ulcers immunostained for CD133 (red), CXCR7 (purple), and CD31 (green). All experiments were performed in triplicate and were repeated three times to confirm the findings (*p < 0.05). Data represent mean ± SD, *p < 0.05, **p < 0.01, ***p < 0.001 versus control; ^##p < 0.01, ^###p < 0.001 versus DM