Fig. 1

Bioinformatics analysis of potential mechanisms of ADSCs affecting neovascularization in high glucose (HG). A Volcano plot of differentially expressed mRNAs depicting upregulated and downregulated genes. B Heat map showing differentially expressed genes in ADSCs treated with LG or HG. C Venn diagram showing 75 shared genes between DEGs and the neovascularization phenotype gene set. D Results of GO analysis. E Results of KEGG analysis. F The PPI network of 75 shared genes. G Seven common hub genes were identified by five algorithms (MCC, MNC, degree, closeness, and radiality) of the cytoHubba plugin. H Representative images of tissue sections from patients with diabetic ulcers immunostained for CXCL12 (green). GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; BP, biological process; CC, cellular component; MF, molecular function; FGF7, fibroblast growth factor 7; FGF18, fibroblast growth factor 18; FGF1, fibroblast growth factor 1; TEK, TEK receptor tyrosine kinase; KIT, proto-oncogenic receptor tyrosine kinase