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Fig. 5 | Cellular & Molecular Biology Letters

Fig. 5

From: Regulating chemoresistance and cancer stemness: the CDH17-YAP pathway in distinct cellular states of lung cancer CTC clusters

Fig. 5

CDH17 is highly expressed in suspension-cultured CTC-TJH-01 cells. A Transcriptomic and proteomic analysis of differentially expressed genes and proteins between adherent and suspension-cultured CTC-TJH-01 cells. B Heatmap of differentially expressed genes. C Western blot analysis of CDH17 and YAP signaling pathway protein expression in adherent and suspension-cultured CTC-TJH-01 cells. D Immunofluorescence analysis of CDH17 protein expression in adherent and suspension-cultured CTC-TJH-01 cells. Scale bar, 50 μm. E Immunohistochemical analysis of CDH17 protein expression in adherent and suspension-cultured CTC-TJH-01 cell xenograft tumors. Scale bar, 100 μm. F Overexpression of the CDH17 gene in adherent-cultured CTC-TJH-01 cells. The left panel displays the western blot analysis, whereas the right panel presents the quantification of protein expression levels. G Expression of the CDH17 gene in lung adenocarcinoma and adjacent tissues. H Expression of the CDH17 gene in lung adenocarcinoma tissues at different clinical stages. I Survival analysis of patients with lung adenocarcinoma stratified by the expression level of the CDH17 gene. Each bar represents the mean ± SD of three separate experiments. *P < 0.05; **P < 0.01; ***P < 0.001

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