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Fig. 1 | Cellular & Molecular Biology Letters

Fig. 1

From: VEXAS, Chediak–Higashi syndrome and Danon disease: myeloid cell endo-lysosomal pathway dysfunction as a common denominator?

Fig. 1

Expression of UBA1, LYST and LAMP in the myeloid lineage. A UBA1, LYST and LAMP2 mRNA expression follow identical trajectories during development of the myeloid lineage. Relatively low in hematopoietic stem cells (HSC) and multipotent myeloid progenitors (MMP), granulocytic/monocytic progenitors (GMP), monocytes (Mono) and drastically decreases in polymorphonuclear (MPP), UBA1, LYST and LAMP2 mRNA expression increases in polymorphonuclear neutrophiles (PMN). The data used to generate these Hierarchical Differentiation Tree was obtained from a cohort known as “normal hematopoiesis with AMLs” through the bloodspot website (https://bloodspot.eu/)

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Cellular & Molecular Biology Letters

ISSN: 1689-1392

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