Tumor-derived exosomal KPNA2 activates fibroblasts and interacts with KIFC1 to promote bladder cancer progression, a process inhibited by miR-26b-5p

Table 2 Correlation of KIFC1 and KPNA2 with clinicopathological characteristics of patients with BCa (IHC)

Clinic-pathologic variables	No. of cases	KIFC1 expression		χ²	Ρ	KPNA2 expression		χ²	Ρ⁽¹⁾
Clinic-pathologic variables	No. of cases	Low	High	χ²	Ρ	Low	High	χ²	Ρ⁽¹⁾
All cases	52	13	39			12	40
Sex				0.0	1.0			0.596	0.44
Male	44	11	33			11	33
Female	8	2	6			1	7
Age (years)				0.578	0.447			0.032	0.858
≤ 60	12	2	10			3	9
> 60	40	11	29			9	31
Tumor size(cm)				5.419	0.02			0.004	0.95
< 3	9	5	4			2	7
≥ 3	43	8	35			10	33
Primary tumor stage				3.258	0.071			7.823	0.005
Tis–T1	14	6	8			7	7
T2–T4	38	7	31			5	33
pN status				2.261	0.133			0.157	0.692
N−	46	13	33			11	35
N +	6	0	6			1	5
Pathology grade				0.693	0.405			0.849	0.357
Low grade	2	0	2			1	1
High grade	50	13	37			11	39
Years of survival				0.447	0.578			0.924	0.336
≤ 5 years		9	31			8	32
> 5 years		4	8			4	8

ISSN: 1689-1392