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Fig. 3 | Cellular & Molecular Biology Letters

Fig. 3

From: Maternal high-fat diet orchestrates offspring hepatic cholesterol metabolism via MEF2A hypermethylation-mediated CYP7A1 suppression

Fig. 3

Maternal high-fat diet disturbs hepatic cholesterol metabolism by suppressing CYP7A1 expression in offspring at weaning. A GO enrichment analysis. B KEGG pathway analysis. C mRNA expression of genes involved in cholesterol metabolism. D Representative immunoblot images for CYP7A1. E Immunoblot analysis of CYP7A1. F Representative immunohistochemistry images for CYP7A1. G Immunohistochemistry analysis of CYP7A1. The scale bar indicates 50 μm. F1, the second generation (offspring); Ctrl, standard diet; HFD, high-fat diet; GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; Ldlr, low-density lipoprotein receptor; Sr-bi, scavenger receptor class B type I; Hmgcr, 3 hydroxy-3 methylglutaryl CoA reductase; Cyp7a1, cholesterol 7α-hydroxylase; Cyp8b1, cytochrome P450 family 8 subfamily B member 1; Abcg5, ATP binding cassette subfamily G member 5; Abcg8, ATP binding cassette subfamily G member 8. Data presented as the mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 versus F1-Ctrl group. n = 3 litters for each group for RNA-seq. n = 6 litters for F1-Ctrl and F1-HFD group, one male offspring per litter

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Cellular & Molecular Biology Letters

ISSN: 1689-1392

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