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Fig. 6 | Cellular & Molecular Biology Letters

Fig. 6

From: Salivary gland protective and antiinflammatory effects of genistein in Sjögren’s syndrome by inhibiting Xist/ACSL4-mediated ferroptosis following binding to estrogen receptor-alpha

Fig. 6

Genistein downregulated ACSL4 to reduce inflammation and ferroptosis in SGECs. A Western blots of ACSL4. B Western blots of AQP5, SSB, and ACSL4 proteins in ACSL4-knockdown SGECs. The MDA (C) and GSH (D) levels in ACSL4-knockdown SGECs. E Representative images of FerroOrange staining in ACSL4-knockdown SGECs. F Western blots of AQP5, SSB, and ACSL4 proteins in ACSL4-overexpression SGECs. MDA (G) and GSH (H) levels in ACSL4-overexpression SGECs. I Representative images of FerroOrange staining ACSL4-overexpression SGECs. J Western blots of AQP5, SSB, and ACSL4 proteins in genistein-treated ACSL4-overexpression SGECs. MDA (K) and GSH (L) levels in genistein-treated ACSL4-overexpression SGECs. M Representative images of FerroOrange staining and quantification in genistein-treated ACSL4-overexpression SGECs. Significant differences are indicated as: *p < 0.05, **p < 0.01, and ***p < 0.001, ns, not significant; n = 3

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Cellular & Molecular Biology Letters

ISSN: 1689-1392

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