Table 1 CircRNAs modulated by EIF4A3

CircRNAs upregulated by EIF4A3

 Breast cancer

circPRKCI

miRNA sponge (miR-545-3p)

Pro-tumor, proliferation, apoptosis, metastasis

[221]

circ_0042881

miRNA sponge (miR-217)

Pro-tumor, proliferation, metastasis,

[222]

circSEPT9

miRNA sponge (miR-637)

Pro-tumor, proliferation, migration, invasion

[132]

circSERPINE2

miRNA sponge (miR-513a-5p)

Pro-tumor, tumor microenvironment

[142]

circZFAND6

miRNA sponge (miR-647)

Pro-tumor, proliferation, metastasis

[223]

circBRWD3

miRNA sponge (miR-142-3p and miR-142-5p)

Pro-tumor, proliferation, migration, invasion

[224]

circWAC

miRNA sponge (miR-599)

Pro-tumor, proliferation, apoptosis, migration, invasion, glycolysis

[225]

hsa_circ_0088088

miRNA sponge (miR-135-5p)

Pro-tumor, proliferation, metastasis

[226]

circIKBKB

Protein binding

Pro-tumor, metastasis

[131]

 Bladder cancer

circSTX6

miRNA sponge (miR-515-3p), protein binding

Pro-tumor, metastasis, therapy sensitivity (cisplatin)

[227]

circ0008399

Protein binding

Pro-tumor, apoptosis, therapy sensitivity (cisplatin)

[145]

 Cholangiocarcinoma

circZNF609

miRNA sponge (miR-432-5p)

Pro-tumor, proliferation, migration, invasion

[228]

 Colorectal cancer

circ_0084615

miRNA sponge (miR-599)

Pro-tumor, proliferation, migration, invasion, angiogenesis

[229]

 Gastric cancer

circGLIS3

miRNA sponge (miR-1343-3p), protein binding

Pro-tumor, proliferation, metastasis

[230]

circABCA5

Protein binding

Pro-tumor, proliferation, migration, invasion

[231]

hsa_circ_001988

miRNA sponge (miR-197-3p)

Antitumor, proliferation, metastasis

[232]

 Glioma

circGRIK2

miRNA sponge (miR-1303)

Pro-tumor, proliferation, migration, invasion

[233]

circCCNB1

miRNA sponge (miR-516b-5p), protein binding

Pro-tumor, proliferation

[234]

 Glioblastoma

circASAP1

miRNA sponge (miR-502-5p), protein binding

Pro-tumor, proliferation, therapy sensitivity (temozolomide)

[134]

circMMP9

miRNA sponge (miR-124)

Pro-tumor, proliferation, migration, invasion

[235]

 Hepatocellular carcinoma

circCCAR1

miRNA sponge (miR-127-5p)

Pro-tumor, proliferation, metastasis, T cell exhaustion, therapy sensitivity (anti-PD1)

[86]

circCDYL

Protein binding

Pro-tumor, metastasis, EMT

[236]

circTOLLIP

miRNA sponge (miR-516a-5p)

Pro-tumor, proliferation, metastasis, EMT

[237]

circRHBDD1

Protein binding

Pro-tumor, proliferation, glycolysis, therapy sensitivity (anti-PD1)

[141]

 Lung cancer

circRABL2B

Protein binding

Antitumor, proliferation, metastasis, stemness, therapy sensitivity (erlotinib)

[238]

circSCAP

miRNA sponge (miR-7)

Pro-tumor, proliferation, metastasis

 Nasopharyngeal carcinoma

circFIP1L1

miRNA sponge (miR-1253)

Pro-tumor, proliferation, apoptosis, therapy sensitivity (radiotherapy)

[239]

 Osteosarcoma

circPRKAR1B

miRNA sponge (miR-361-3p)

Antitumor, proliferation, metastasis, EMT, therapy sensitivity (cisplatin)

[135]

 Pancreatic cancer

circRNF13

miRNA sponge (miR-654-3p)

Pro-tumor, proliferation, angiogenesis, invasion, glycolysis

[240]

 Prostate cancer

circTFDP2

Protein binding

Pro-tumor, proliferation, metastasis

[241]

circARHGAP29

Protein binding

Pro-tumor, proliferation, angiogenesis, invasion, glycolysis

[133]

miRNA sponge (miR-133a-3p and miR-133b)

Antitumor, therapy sensitivity (enzalutamide)

[242]

CircRNAs downregulated by EIF4A3

 Cervical cancer

circ_0087429

miRNA sponge (miR-5003-3p)

Antitumor, proliferation, metastasis, angiogenesis, EMT

[138]

 Colorectal cancer

circβ-catenin

miRNA sponge (miR-197-3p)

Pro-tumor, proliferation, metastasis

[243]

circ_0009092

miRNA sponge (miR-665)

Pro-tumor, proliferation, invasion, TAM recruitment

[136]

circPTEN1

Protein binding

Antitumor, metastasis, EMT

[137]

 Gastric cancer

circ_100290

miRNA sponge (miR-29b-3p)

Pro-tumor, proliferation, migration, invasion, EMT

[244]

 Laryngeal squamous cell carcinoma

hsa_circ_0001445

miRNA sponge (hsa-miR-432-5p)

Pro-tumor, proliferation, migration, invasion

[245]

 Lung cancer

circ_0067716

miRNA sponge (miR-324-5p), protein binding

Anti-tumor, proliferation, apoptosis

[246]