Fig. 4

Knockdown of SERPINE2 inhibited the TGF-β1-induced fibrosis of LF cells. A, B The efficacy of SERPINE2 knockdown was assessed using the western blot. C–G The mRNA and protein expression of fibrosis-related markers after the SERPINE2 knockdown was evaluated using the qRT-PCR and western blot. H, I The protein expression of SERPINE2 after the SERPINE2 overexpression was evaluated using the western blot. J–N The mRNA and protein expression of fibrosis-related markers in the rescue experiments between miR-335-3p and SERPINE2. ns, not significant; *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001