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Fig. 2 | Cellular & Molecular Biology Letters

Fig. 2

From: Epigenetic modification regulates the ligamentum flavum hypertrophy through miR-335-3p/SERPINE2/β-catenin signaling pathway

Fig. 2

Overexpression of miR-335-3p inhibited the TGF-β1-induced fibrosis of LF cells. A–E The mRNA and protein expression of fibrosis-related markers after the TGF-β1 treatment. F, G The volcano plot and heat map of differently expressed miRNAs after the TGF-β1 treatment. H The abundance of miR-335-3p after the TGF-β1 treatment. I The expression of miR-335-3p in LF tissues was evaluated using the qRT-PCR. J The transfection efficiency of miR-335-3p mimics was checked using the qRT-PCR. K–O The mRNA and protein expression of fibrosis-related markers after the miR-335-3p overexpression using the qRT-PCR and western blot. *P < 0.05, **P < 0.01, and ****P < 0.0001

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Cellular & Molecular Biology Letters

ISSN: 1689-1392

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