Fig. 8
From: The miR-1269a/PCDHGA9/CXCR4/β-catenin pathway promotes colorectal cancer invasion and metastasis
miR-1269a and PCDHGA9 together affect the invasion and metastasis of CRC in vivo. a Whole-body fluorescence images showing lung metastases across varying conditions of miR-1269a and PCDHGA9 expression. Subsequent photos depicted lung metastases following the sacrifice of these mice. b Immunohistochemical staining of lung metastases was carried out for E-cadherin and vimentin. The immunohistochemical staining highlighted alterations in E-cadherin and vimentin expression in response to different miR-1269a and PCDHGA9 expression conditions. miR-1269a reduced the expression of E-cadherin, but this result was reversed in the condition of high expression of PCDHGA9. Vimentin showed the opposite of E-cadherin