Fig. 6

Hierarchical cluster analysis of integrated gene expression data from 6-month-old Mcpip1fl/fl and Mcpip1fl/fl LysMCre. A Heat map showing down- and upregulation of manually selected genes reported to be involved in LSEC pathology and speculated to have a role in the regulation of LSEC porosity. B Up- and downregulated biological processes changed in LSECs from the Mcpip1 KO group. C Comparison of selected gene expression for 3-month-old and 6-month-old by RT-PCR. n = 4–5 animals