Fig. 1

Structure of the MUC1 gene encoding the MUC1-N and MUC1-C subunits. A MUC1 sequences emerged from MUC5B. B Schematic representation of the MUC1-C gene, which consists of 7 exons (E1–E7) and 6 introns (I1–I6). MUC1-N is encoded by exons 1–4 and MUC1-C encoded by exons 4–7. C Schematic representation of the MUC1-C gene, which consists of seven exons (E1–E7) and six introns (I1–I6). MUC1-N is encoded by exons 1–4 and MUC1-C is encoded by exons 4–7. Structure of MUC1, consisting of extracellular domain (ED), transmembrane domain (TM), and cytoplasmic domain (CD). MUC1 releases MUC1-N into the protective physical barrier in response to inflammation