Chemokine CXCL13–CXCR5 signaling in neuroinflammation and pathogenesis of chronic pain and neurological diseases

Table 1 Summary of cellular distribution of CXCL13–CXCR5 in different models of pain or neurological diseases

Tissue type	Models for pain or neurological diseases	Marker	Cell type	Colocalized with	References
Ipsilateral hemisphere	tMCAO	ICAM-1	ICAM-1⁺cell	CXCL13	[107]
		CD4	CD4⁺cell	CXCL13–CXCR5
Anterior cingulate cortex	SNL	NeuN	Neuron	Cxcl13/CXCR5	[44]
Trigeminal ganglion	pIONL	β-III tubulin	Neuron	CXCL13–CXCR5	[36]
Spinal cord	SNL	NeuN	Neuron	CXCL13–CXCR5	[35]
		MAP2	Neuron	CXCL13
		GFAP	Astrocyte	CXCR5
	PDN	NeuN	Neuron	CXCL13–CXCR5	[48]
		GFAP	Astrocyte	CXCR5
		CD11b	Microglia	CXCR5
	CPIP	NeuN	Neuron	CXCL13–CXCR5	[34]
		GFAP	Astrocyte	CXCL13–CXCR5
	ALS	Neurotrace	Motor neuron	CXCL13–CXCR5	[104]
		CD68	Microglia	CXCL13
Sciatic nerves	ALS	NF200	Efferent motor axon	CXCL13	[104]
		S100β	Bundles of Schwann cell	CXCR5
		Smi32	Peripheral axon	CXCL13–CXCR5
Dorsal root ganglion	SNL	TUJ1	Neuron	CXCL13	[40]
	CFA	IB4	Nonpeptidergic C-nociceptor	CXCL13–CXCR5	[37]
		CGRP	Peptidergic C-nociceptor
		NF200	A-fiber afferent

ISSN: 1689-1392