Fig. 4
From: Research progress of ankyrin repeat domain 1 protein: an updated review

Ankrd1 participates in tumor progression. Ankrd1 inhibits apoptosis by Bcl2 and GADD153. Ankrd1 promotes stemness and proliferation of breast cancer stem cells. Ankrd1 enhances drug resistance, such as cisplatin, phenylbutyrate, afatinib, and osimertinib. Ankrd1 promotes tumor migration and invasiveness by inhibiting apoptosis in colorectal cancer cell lines. Ankrd1 activates the pro-tumorigenic properties of cancer-associated fibroblasts via AP-1 complex