Table 3 Caspase-8 related influencing factors

zVAD-fmk

zVAD-fmk is a pan-caspase inhibitor used to block apoptosis

[295,296,297]

QVD

QVD operates as a robust, irreversible inhibitor of broad-spectrum caspases, effectively thwarting apoptosis across diverse cell lines

[295, 298]

VX-166

VX-166 is a caspase inhibitor that inhibits the activity of caspase, to a certain extent playing the same role as QVD

[299]

CrmA

CrmA, a viral serpentine protein, inhibits certain cysteine proteases, such as caspase-1 and caspase-8

[300]

zIETD-fmk

zIETD-fmk is a selective caspase-8 inhibitor, commonly used in research to block the enzyme’s activity

[297, 301, 302]

Ac-IETD-CHO

Ac-IETD-CHO is a selective caspase-8 inhibitor that can be used to selectively inhibit caspase-8

[303, 304]

ZINC19370490

ZINC19370490 refers to a specific chemical compound listed in the ZINC database. It may be a potent caspase-8 inhibitor, but it is not yet proven

[305]

ZINC04534268

ZINC04534268 refers to a specific chemical compound listed in the ZINC database. It may be a potent caspase-8 inhibitor, but it is not yet proven

[305]

ZINC38200481

ZINC38200481 refers to a specific chemical compound listed in the ZINC database. It may be a potent caspase-8 inhibitor, but it is not yet proven

[151]

ZINC01576107

ZINC01576107 refers to a specific chemical compound listed in the ZINC database. It may be a potent caspase-8 inhibitor, but it is not yet proven

[151]

ZINC02384806

ZINC02384806 refers to a specific chemical compound listed in the ZINC database. It may be a potent caspase-8 inhibitor, but it is not yet proven

[151]

ZINC38570006

ZINC38570006 refers to a specific chemical compound listed in the ZINC database. It may be a potent caspase-8 inhibitor, but it is not yet proven

[151]

ZINC38569951

ZINC38569951 refers to a specific chemical compound listed in the ZINC database. It may be a potent caspase-8 inhibitor, but it is not yet proven

[151]

Positive effect on caspase-8

(Smac) mimetics

(Smac) mimetics refer to small-molecule inhibitors that mimic the action of the second mitochondria-derived activator of caspases (Smac), targeting proteins that inhibit apoptosis, thereby promoting the activation of caspase-8 and subsequent induction of apoptosis

[307, 308]

PS-341

PS-341 can activate caspase-8 and promote apoptosis

[309, 310]

Lenalidomide

Lenalidomide can activate caspase-8 and promote apoptosis

[309, 310]

Paclitaxel

Paclitaxel can facilitate the activation of caspase-8 and thereby inducing apoptosis mediated by this enzyme

[311, 312]

Doxorubicin

Doxorubicin can facilitate the activation of caspase-8 and thereby inducing apoptosis mediated by this enzyme

[313]

Etoposide

Etoposide can facilitate the activation of caspase-8 and thereby inducing apoptosis mediated by this enzyme

[313, 314]