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Table 2 Caspase-8 related modifications and regulatory types

From: Caspase-8 in inflammatory diseases: a potential therapeutic target

Modification type

Specific site

Functional impact

Associated conditions or processes

References

Methylation

CpG sites in promoter

Suppresses mRNA expression

Hepatocellular carcinoma, malignant gliomas

[259, 260]

Phosphorylation

Tyrosine residues: Y397, Y380, Y465; serine residues: S387, S305

Modulates apoptotic capacity

Apoptosis regulation

[239, 266,267,268]

Threonine residue: T273 (by Plk3)

Pro-apoptotic effect

DISC formation, apoptosis

[266]

Tyrosine residues: Y397, Y465 (by Lyn)

Inhibits caspase-8 cleavage and activation

Apoptosis inhibition

[185]

Tyrosine residues: Y397, Y465, Y380 (by Src kinase)

Reduces procaspase-8 maturation rates

Precursor maturation

[259, 260]

Serine residues: S387, S305 (by ERK1/2 CDK1, Plk1)

Prevents apoptosis

Apoptosis inhibition

[266,267,268, 271]

Dephosphorylation

Tyrosine residue: Y310 (by SHP-1)

Promotes apoptosis

Apoptosis regulation

[239]

Ubiquitination

Not specified

Modulates activity, inhibits caspase-8

Apoptosis, necroptosis, cancer,

neurological disorders

[261, 272,273,274,275]

S-nitrosylation

Not specified

Protects against TNF-a/ActD-induced apoptosis

Hepatocyte protection, apoptosis

inhibition

[262]

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Cellular & Molecular Biology Letters

ISSN: 1689-1392

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