Fig. 4

Schematic representation of PANoptosis and the associated triad of cell death pathways. PANoptosis embodies a comprehensive form of cell death that incorporates pyroptosis, apoptosis, and necroptosis. It is governed by a cytoplasmic protein conglomerate known as the PANoptosome, which encompasses core elements from various cell death modalities, including caspase-8. Within PANoptosis, the inhibition of one death pathway precipitates the activation of an alternative inflammatory cell death route. The PANoptosome serves as a conceptual scaffold, orchestrating the recruitment of pivotal molecules from disparate cell death pathways to facilitate the process of inflammatory cell death (by Figdraw)