Fig. 4

Bioinformatic analysis of SOX10 dependencies on p53 pathway. A The dependence of 64 melanoma cell lines for SOX10 gene effect from CRISPR (DepMap Public 23Q2 + Score, Chronos) on the x-axis (0 is equivalent to a gene that is not essential, less than −1 corresponds to essential genes) to TP53 mutation status on the y-axis (0 is no mutation, 1 is other mutations, 2 is damaging mutation as defined by DepMap portal). A375, HT144, and RPMI7951 are highlighted. The table shows Pearson and Spearman correlation coefficients for all cell lines and for melanoma cell lines. B The co-dependent genes for SOX10 from CRISPR (DepMap Public 23Q2 + Score, Chronos), showing the top five genes and the p53-related genes among the top 100 co-dependent genes, with their Pearson correlation coefficients indicating the strength of co-dependency between SOX10 and the indicated genes. C Venn diagram showing genes significantly co-expressed between TP53 and SOX10 (in intersection). The mRNA data were downloaded from cbioportal.org. D KEGG pathway enrichment analysis of genes significantly co-expressed with TP53 and SOX10. Visualized by ShinyGo0.77