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Fig. 3 | Cellular & Molecular Biology Letters

Fig. 3

From: Inverse correlation between TP53 gene status and PD-L1 protein levels in a melanoma cell model depends on an IRF1/SOX10 regulatory axis

Fig. 3

SOX10 dependence on TP53 status and its impact on IRF1. A Western blots in A375 and HT144 (wt p53), and A375p53KO and RPMI7951 (p53-null) cells with or without 1 μM AMG-232 for 24 h. IRF1, SOX10, IRF4, p53, p21, and β-actin (as loading control) have apparent molecular weights of 55, 55, 55, 53, 21, and 42 kDa, respectively. B Western blots in A375, A375p53KO, and single cell A375 derivatives with SOX10 deletion (A375SOX10KO). IRF1, SOX10, and β-actin (as loading control) have apparent molecular weights of 55, 55, and 42 kDa, respectively. C, D Western blots of the indicated proteins in (C) A375 and A375p53KO, and (D) in RPMI7951 (p53-null) cells transfected with pCDNA3-p53 (p53) or empty vector (EV) for 24 h and 48 h. IRF1, SOX10, p53, p21, and β-actin (as loading control) have apparent molecular weights of 55, 55, 53, 21, and 42 kDa, respectively. Stripped and re-probed blots are indicated by arrows

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Cellular & Molecular Biology Letters

ISSN: 1689-1392

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