Fig. 5

HDAC3 inhibition improves motor behaviour and tissue infarction after I/R. After PTS, ITSA1 and/or RGFP966 were administered via intraperitoneal injection, MCAO/R mice underwent neurological tests twice before surgery and at 1, 2 and 3 days after MCAO/R; testing included assessment of the neurological deficit score (A) and performance in the hidden platform trial of the MWM (B). The data are presented as the means ± SEMs (n = 8). C Representative images of TTC staining at 24 h after MCAO/R and quantitative analysis of the hemispheric infarct ratio. HDAC activation (D) and the levels of the inflammatory factors TNF-α and IL-1β (E) in ischaemic brain tissue 1 day after MCAO/R. The data are presented as the means ± SEMs (n = 5). *p < 0.05, versus the sham group; #p < 0.05, versus the MCAO/R + vehicle group; &p < 0.05, versus the MCAO/R + ITSA1 group