Fig. 1

PTS improves motor behaviour and tissue infarction after I/R. PTS (1 mg/kg, 5 mg/kg or 10 mg/kg) was administered via intraperitoneal injection immediately after MCAO/R, and neurological tests were conducted twice before surgery and 1 day, 2 day and 3 day after MCAO/R, including assessment of the neurological deficit score (A) and performance in the hidden platform trial of the MWM (B). The data are presented as the means ± SEMs (n = 8). C Representative images of TTC staining at 24 h after MCAO/R and quantitative analysis of the hemispheric infarct ratio. Total HDAC activation (D) and the levels of the inflammatory factors TNF-α and IL-1β (E) in ischaemic brain tissue at 1 d after MCAO/R. The data are presented as the means ± standard error of the means (SEMs; n = 5). *p < 0.05, versus the sham group; #p < 0.05, versus the MCAO/R group. L, PTS 1 mg/kg; M, PTS 5 mg/kg; H, PTS 10 mg/kg