Lysosome quality control in health and neurodegenerative diseases

Table 2 Genes mutated in NDs which induce lysosome alterations

Gene	Role in lysosome damage	ND-related	References
SNCA	Toxicity mediated by aggregation	PD	[54, 171]
C9ORF72	Toxicity mediated by aggregation	ALS/FTD	[240]
TARDBP	Toxicity mediated by aggregation and loss of function	ALS/FTD	[195, 196]
MAPT	Toxicity mediated by aggregation and loss of function	FTD/ALS	[199, 200]
FUS	Toxicity mediated by aggregation	ALS	[202]
IT15	Toxicity mediated by aggregation	HD	[241]
APP	Toxicity mediated by aggregation	AD	[215]

ISSN: 1689-1392