MicroRNAs in metabolism for precision treatment of lung cancer

Table 1 MicroRNAs involved in LC metabolic rewiring

miRNA	Target (direct and indirect)	Function	References
miR-133b	PKM2	Inhibition of glycolysis	[17]
miR-155	HK2	Induction of glycolysis	[21]
miR-33b	LDHA	Inhibition of glucose metabolism	[22]
miR-6077	GLUT1	Inhibition of glucose metabolism	[25]
miR-199a-5p	SLC2A1/GLUT1	Inhibition of glucose metabolism	[26]
miR-144	GLUT1	Inhibition of glucose metabolism	[27]
miR-124	GLUT1, HK2	Inhibition of glucose metabolism	[28]
miR-128	PFKL	Inhibition of glucose metabolism	[31]
miR-21	HIF1a, LDHA, HKII	Induction of glycolysis	[34, 35]
miR-21	FBP1	Induction of glycolysis	[36]
miR-21	CD36, PPARGC1B	Induction of fatty acid metabolism	[40]
miR-15a-5p	ACSS2	Inhibition of lipid metabolism	[41]
miR-421	PTEN	Induction of lipid metabolism	[42]
miR-126	SLC7A5	Inhibition of essential aa transport	[45]
miR-99a	NOX4	Regulates ROS levels by downregulation of MMP2 and MMP9	[49]
miR-506	NF-kB p65	Increased ROS production	[50]
miR-551b	Catalase	Increased ROS production	[51]
miR-200c	PRDX2, Nrf2, SESN1	Increased ROS accumulation	[52]
miR-22-3p	MTHFD2, MTHFR	Inhibition of folate metabolism	[70]
miR-9-5p	SHMT1 MTHFD1L, MTHFD2	Inhibition of folate metabolism	[70]
miR-218-5p	SHMT1	Inhibition of folate metabolism	[70]

PKM2 piruvate kinase isoenzyme 2, HK2 hexokinase, LDHA lactate dehydrogenase, GLUT1/SLC2A1 glucose transporter 1, PFKL phosphofructokinase, FBP1 fructose-1,6-bisphosphatase, CD36 fatty acid translocase, PPARGC1B peroxisome proliferator-activated receptor gamma coactivator 1-beta, ACSS2 acyl-coenzyme A synthetase short-chain, PTEN phosphatase and tensin homolog, SLC7A5 solute carrier family 7 member 5, NOX4 NADPH oxidase 4, NF-kB nuclear factor kappa-light-chain-enhancer of activated B cells, PRDX2 peroxiredoxin-2, Nrf2 nuclear factor erythroid-2-related factor 2, SESN1 sestrin 1, MTHFD2 mitochondrial bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, MTHFR methylene tetrahydrofolate reductase, SHMT1 cytosolic form of serine hydroxymethyltransferase, MTHFD1L mitochondrial monofunctional C1-tetrahydrofolate synthase, MTHFD2 mitochondrial bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase

ISSN: 1689-1392