Fig. 7
From: CLDN6 inhibits breast cancer growth and metastasis through SREBP1-mediated RAS palmitoylation
In vivo, CLDN6 inhibits BC progression through RAS palmitoylation. A Images of subcutaneous xenograft tumors (n = 5). B–D Tumor volume (B, C) and weight (D) of subcutaneous xenograft tumors. E Visualization of the expression levels and localization of CLDN6, SREBP1, and RAS in transplanted tumor tissue. Scale bar, 20 μm. F, G Analysis of lung metastasis using bioluminescent techniques (n = 4). H, I Lung metastatic nodes were indicated with red arrowheads. J, K The lung metastasis of BC was observed through H&E staining. Scale bar, 5 mm and 500 μm. *P < 0.05, **P < 0.01, ***P < 0.001 denoted statistically significant differences