Fig. 6
From: CLDN6 inhibits breast cancer growth and metastasis through SREBP1-mediated RAS palmitoylation
CLDN6 sequesters KLF5 in the cytoplasm through its interaction with MAGI2. A–C The interaction among CLDN6, MAGI2, and KLF5 in MDA-MB-231/CLDN6 cells. D The interaction between CLDN6 and MAGI2 or KLF5 in MDA-MB-231/CLDN6δPBM cells. E The alteration of SREBP1 expression in MAGI2-knockdown BC cells (n = 3). F-G The interaction between CLDN6 and KLF5 in BC cells with MAGI2 knockdown. H, I The effect of MAGI2-knockdown on localization (red) (H) and distribution of KLF5 (I) (n = 3) in BC cells with CLDN6 overexpression. Scale bar, 20 μm. *P < 0.05, **P < 0.01, ***P < 0.001 denoted statistically significant differences