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Fig. 3 | Cellular & Molecular Biology Letters

Fig. 3

From: Palmitoylation of synaptic proteins: roles in functional regulation and pathogenesis of neurodegenerative diseases

Fig. 3

Palmitoylation in regulating AMPAR trafficking. As the AMPAR heteromers are assembled in ER, it is the start site for synaptic trafficking. Palmitoylation of AMPAR2 (GluA2) in the ER is crucial for its sorting to the lysosome for degradation. After trafficking to Golgi, the AMPAR1/2 (GluA1/2) are palmitoylated by DHHC3 to prevent their trafficking to plasma membrane and keep them in Golgi. Interestingly, the depalmitoylation of AMPARs in Golgi is a releasing signal for trafficking of AMPARs from Golgi to the membrane, where the AMPARs are palmitoylated again for the AMPARs internalization. Some functional protein pools may exist in the ER, Golgi, and membrane regions, for triggering the palmitoylation/depalmitoylation process of AMPARs; however, detailed information is lacking

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Cellular & Molecular Biology Letters

ISSN: 1689-1392

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