Fig. 2
METTL3 regulates m6A modification and promotes tumour growth in LUAD. A, D The m6A level in METTL3 overexpressing and knockdown cells. B, E CCK-8 analysis of A549 and H1299 cell viability with METTL3 knockdown or overexpression. C, F Quantification bar chart of the EdU analysis of METTL3 overexpressing and knockdown A549 and H1299 cells. G Representative images of control and METTL3-overexpressing xenograft tumours. H Tumour volume of the control and METTL3 overexpression groups measured at day 7, 9, 11, 13, 15, 17, 19, 21, 23 and 25 after subcutaneous injection. I Tumour weight of the control and METTL3 overexpression groups after sacrifice. Data illustrated as the mean [± standard deviation (SD)] of three independent experiments. Two-way analysis of variance (ANOVA) and unpaired t-tests were carried out to verify the statistical significance. *P < 0.05; **P < 0.01; ***P < 0.001