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Fig. 2 | Cellular & Molecular Biology Letters

Fig. 2

From: New mechanistic understanding of osteoclast differentiation and bone resorption mediated by P2X7 receptors and PI3K-Akt-GSK3β signaling

Fig. 2

The metabolomic analysis demonstrates altered bone metabolism induced by P2X7 activation. A Workflow for LC/MS detection and metabolomic analysis of mouse fecal samples; B principal component analysis (PCA) score plot. C orthogonal projections to latent structures discriminant analysis (OPLS-DA) score plot. D heatmap of 33 differentially regulated metabolites. E scatter plot of KEGG enrichment analysis for differentially regulated metabolites; F circular plot of KEGG enrichment analysis for differentially regulated metabolites; G lollipop plot of KEGG pathway enrichment analysis for differentially regulated metabolites, with larger dots representing more associated metabolites and the red box highlighting the PI3K-AKT signaling pathway with the highest relevance. In total, ten mice were used in each group for the study

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Cellular & Molecular Biology Letters

ISSN: 1689-1392

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