Fig. 1

Transcriptional profiling reveals the key pathways influenced by the P2X7 receptor in OP. A Volcano plot of differential expression analysis based on transcriptome sequencing; B heatmap of selected differentially expressed genes; C Venn diagram showing the intersection of genes related to “OP” from the transcriptome sequencing and GeneCards database; D scatter plot of GO and KEGG enrichment analysis; E scatter plot of KEGG enrichment analysis for relevant pathways; F circular plot of KEGG pathway enrichment analysis highlighting the involvement of key genes; G, H enrichment analysis results of the key gene set using GSEA. Three mice per group were used for transcriptome sequencing