Fig. 9

Autophagy Negatively Regulates the Expression of circPTPN22 by Modulating FUS. A qRT-PCR assay to detect the expression levels of circPTPN22 and PTPN22 after adding the autophagy activator Rap and the autophagy inhibitor 3-Ma. B and C Gene and protein expression of RUNX1, FUS, and ELAVL1 in AGS and SGC-7901 cells after the addition of Rap. D and E Gene and protein expression of RUNX1, FUS, and ELAVL1 in AGS and SGC-7901 cells after the addition of the autophagy inhibitor 3-Ma. *p < 0.05, **p < 0.01, ****p < 0.001