Fig. 7

Knockdown of circPTPN22 can inhibit the progression of GC via autophagy in BALB/c nude mice. A Tumors formed by different treatment groups of BALB/c nude mice and tumor growth curves. B Tumor weights of each group at the end of the experiment. C mRNA expression levels of circPTPN22, miR-6788-5p, and PAK1 in different groups validated by qRT-PCR. D Hematoxylin and eosin staining showing the structure of xenograft tumors, scale bar: 200 μM. Immunohistochemistry demonstrating protein expression levels of Ki67, Vimentin, and E-cad in different groups, scale bar: 100 μM and 200 μM. E Immunofluorescence showing protein expression levels of LC3 and P62 in different groups, scale bar: 200 μM. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.001