Fig. 5

PAK1 can directly bind miR-6788-5p. A Bioinformatics analysis of downstream mRNAs associated with autophagy bound by miR-6788-5p. B qRT-PCR assay to detect the expression levels of PAK1 and PRKCA in GC cells after adding miR-6788-5p mimic. C and D Dual luciferase reporter gene assay to detect the binding of PAK1 and miR-6788-5p. E Expression of PAK1 after adding miR-6788-5p inhibitor and mimic or knocking down and overexpressing circPTPN22 in GC cells. F and G Correlation analysis of expression of PAK1 and miR-6788-5p, PAK1 and circPTPN22 in 40 pairs of GC tissues. H Expression of PAK1 in GC and normal tissues in the GEPIA database. I and J Expression of PAK1 in GC tissues and paired normal tissues from the TCGA database. K Expression of PAK1 in GC tissues. **p < 0.01, ***p < 0.001, ****p < 0.001