Fig. 7

ERRα agonist treatment ameliorate cognitive function in Aβ1-42 ICV injected mice. a Experimental design for Aβ1-42 injection and behavioral test (Created with https://www.biorender.com). b Schematic representation of Y-maze task. c–e The spontaneous alternation rates of all mice (c, n = 13, sham group; n = 13, Aβ + vehicle group; n = 14, Aβ + agonist group), male mice (d, n = 7, sham group; n = 7, Aβ + vehicle group; n = 7, Aβ + agonist group), and female mice (e, n = 6, sham group; n = 6, Aβ + vehicle group; n = 7, Aβ + agonist group) in Y-maze were showed. f Schematic representation of NOR task. g–i The novel objective recognition rates of all mice (g, n = 13, sham group; n = 13, Aβ + vehicle group; n = 14, Aβ + agonist group) male mice (h, n = 7, sham group; n = 7, Aβ + vehicle group; n = 7, Aβ + agonist group), and female mice (i, n = 6, sham group; n = 6, Aβ + vehicle group; n = 7, Aβ + agonist group) were showed. j. Representative immunoblotting images of ERRα protein expression from cortex, with the top image representing males and the bottom image representing females. k, l Quantification analysis of cortex ERRα protein expression in male mice (k, n = 4, sham group; n = 3, Aβ + vehicle group; n = 3, Aβ + agonist group) and female mice (l, n = 3, sham group; n = 3, Aβ + vehicle group; n = 4, Aβ + agonist group). m Representative immunoblotting images of PSD95 protein expression from cortex, with the top image representing males and the bottom image representing females. n, o Quantification analysis of cortex PSD95 protein expression in male mice (n n = 4, sham group; n = 3, Aβ + vehicle group; n = 3, Aβ + agonist group) and female mice (o, n = 4, sham group; n = 3, Aβ + vehicle group; n = 4, Aβ + agonist group). c, d, e, g, h, i, k, l, n, o Data were presented as the mean ± S.E; One-way ANOVA; *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001