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Fig. 7 | Cellular & Molecular Biology Letters

Fig. 7

From: FGFR2-triggered autophagy and activation of Nrf-2 reduce breast cancer cell response to anti-ER drugs

Fig. 7

Predicted mechanism of FGFR2-dependent regulation of p62/Keap1/Nrf-2 axis in ER+ BCa. FGF7/FGFR2 signalling induces autophagy in AMPKα/ULK1-dependent manner. FGFR2-mediated p62 serine 349 phosphorylation leads to Keap1/Nrf-2 complex dissociation, followed by Nrf-2 stabilization/increased expression resulted in higher activity of Nrf-2, which might be involved in BCa cell resistance to anti-ER treatment and poor prognosis of patients’. Created with BioRender.com

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Cellular & Molecular Biology Letters

ISSN: 1689-1392

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